SGTA Inhibitors
SGTA inhibitors belong to a class of chemical compounds that have garnered significant attention in the field of molecular biology and drug discovery. These inhibitors target the protein known as SGTA, which stands for Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha. SGTA is a critical player in various cellular processes, particularly in the regulation of protein folding and quality control within the endoplasmic reticulum (ER). To understand the significance of SGTA inhibitors, it is essential to delve into their role in cellular biology.
SGTA is primarily responsible for assisting in the proper folding of newly synthesized proteins in the ER. It acts as a molecular chaperone, ensuring that proteins attain their correct three-dimensional structures, which is crucial for their proper functioning. Additionally, SGTA is involved in the recognition and degradation of misfolded or aberrant proteins, their accumulation and potential toxicity. SGTA inhibitors, therefore, have the capacity to disrupt these vital functions of SGTA, potentially leading to an accumulation of misfolded proteins and disturbances in cellular protein homeostasis. Understanding the mechanisms and effects of SGTA inhibitors can provide valuable insights into the fundamental processes of protein folding and quality control within cells, contributing to advancements in the broader fields of molecular biology and cell biology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to the ATP-binding domain of Hsp90 (Heat shock protein 90), which can interfere with the maturation of Hsp90 client proteins including SGTA, a co-chaperone of Hsp90. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silibinin is a major active constituent of silymarin known to modulate cellular signaling pathways. It can indirectly affect proteins associated with the Hsp90 chaperone complex, which may include SGTA. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide has been shown to disrupt multiple cellular pathways, including those involving heat shock proteins, which could indirectly affect SGTA function. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A disrupts the function of Hsp90 by inducing its aggregation and degradation, which may influence the stability and activity of SGTA. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol has been identified as an inhibitor of Hsp90, potentially impacting co-chaperone proteins such as SGTA by destabilizing their interactions. | ||||||
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $128.00 $380.00 | ||
Novobiocin is known to bind to the C-terminal domain of Hsp90, which can disrupt its chaperone function and influence the activity of associated co-chaperones like SGTA. | ||||||
BIIB 021 | 848695-25-0 | sc-364434 sc-364434A | 5 mg 25 mg | $128.00 $650.00 | ||
BIIB021 is an oral Hsp90 inhibitor that can impact the stability and function of co-chaperones like SGTA by binding to the N-terminal ATP-binding domain of Hsp90. | ||||||
NVP-AUY922 | 747412-49-3 | sc-364551 sc-364551A sc-364551B sc-364551C sc-364551D sc-364551E | 5 mg 25 mg 100 mg 250 mg 1 g 5 g | $150.00 $263.00 $726.00 $1400.00 $2900.00 $11000.00 | 3 | |
NVP-AUY922 is an isoxazole-based Hsp90 inhibitor which may influence the activity of client proteins and co-chaperones such as SGTA. | ||||||
VER 155008 | 1134156-31-2 | sc-358808 sc-358808A | 10 mg 50 mg | $203.00 $842.00 | 9 | |
VER-155008 is a small molecule inhibitor of Hsp70, a chaperone protein that interacts with Hsp90 and its co-chaperones, potentially affecting SGTA function. | ||||||