SEMA4D Activators
SEMA4D ActivatorsSEMA4D Activators comprise a specialized set of chemical compounds that influence cellular signaling pathways to enhance the functional activity of SEMA4D. Compounds such as Forskolin and Rolipram act by elevating intracellular cAMP levels, which in turn activate protein kinase A (PKA). PKA phosphorylates various substrates that integrate with SEMA4D signaling, thereby potentially amplifying SEMA4D's role in neuronal guidance and immune cell regulation. Sphingosine-1-phosphate and Prostaglandin E2 bind to their respective receptors, initiating signaling cascades that intersect with SEMA4D pathways, particularly the PI3K/Akt pathway, which is vital for cellular growth and survival responses that SEMA4D may potentiate. Ionomycin and Thapsigargin, by increasing intracellular calcium concentrations, activate calcium-dependent kinases, potentially enhancing SEMA4D's downstream effects on neurite outgrowth and immune cell activation. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which is involved in cytoskeletal reorganization and cellular adhesion, processes that are critical for SEMA4D's functionality.
The modulation of receptor tyrosine kinases and MAPK signaling by compounds like Epigallocatechin gallate (EGCG), U0126, and SB203580 provides an indirect yet potent mechanism for enhancing SEMA4D activity. EGCG, by modulating tyrosine kinases and calcium signaling, may potentiate SEMA4D's influence on axonal guidance and immune interactions. U0126 and SB203580, inhibitors of MEK1/2 and p38 MAP kinase respectively, may shift the equilibrium of cellular signaling to favor SEMA4D-associated pathways, augmenting its role in cell migration and immune cell interactions. LY294002, while typically a PI3K pathway inhibitor, may paradoxically enhance SEMA4D-related signaling by altering competing pathways. Similarly, CNQX, by inhibiting AMPA receptors, could upregulate compensatory neuronal mechanisms that enhance SEMA4D-mediated synaptic plasticity. Collectively, these SEMA4D Activators engage diverse but interconnected signaling pathways, orchestrating a cellular environment that bolsters SEMA4D's activity without affecting its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin upregulates cyclic AMP (cAMP) by activating adenylate cyclase. Elevated cAMP levels can enhance SEMA4D signaling by promoting its downstream pathways, including the cAMP-dependent protein kinase A (PKA) pathway, which is known to phosphorylate various substrates that could intersect with SEMA4D's functional role in neuronal guidance and immune responses. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) engages S1P receptors, which can trigger intracellular signaling cascades such as the PI3K/Akt pathway. This pathway has been implicated in promoting survival and growth responses that can potentiate SEMA4D's role in axonal growth cone collapse and immune cell regulation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased intracellular cAMP levels. This can enhance the PKA signaling cascade that intersects with SEMA4D-mediated pathways, thus potentially enhancing SEMA4D's effects on cytoskeletal organization and cellular motility. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can modulate PI3K/Akt signaling pathways. While typically a negative regulator, in the context of SEMA4D, it can shift the cellular signaling balance, potentially enhancing pathways that are positively regulated by SEMA4D, such as those involved in immune cell activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin raises intracellular calcium levels by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Elevated calcium may activate calcium-dependent protein kinases which can phosphorylate substrates that are part of SEMA4D's signaling cascade, involved in neuronal patterning and immune responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a potent activator of protein kinase C (PKC). PKC activation can influence the cytoskeletal rearrangements and cellular adhesion processes in which SEMA4D is known to participate, thus potentially enhancing its functional activity. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $204.00 | 2 | |
CNQX is an AMPA receptor antagonist that can modulate glutamatergic signaling. By inhibiting these receptors, CNQX may upregulate compensatory mechanisms in neurons that could enhance SEMA4D-dependent signaling pathways related to synaptic plasticity and neuron-neuron communication. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor that can alter the balance of cellular signaling. By inhibiting p38, it may indirectly enhance SEMA4D-dependent pathways involved in cell migration and immune cell interaction by reducing competitive signaling through the p38 pathway. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its EP receptors to modulate cyclic AMP levels, which can influence the PKA pathway. This modulation may enhance SEMA4D signaling involved in inflammatory responses and contribute to SEMA4D's role in immune cell regulation. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. The resultant calcium signaling could potentially enhance SEMA4D's activation and its downstream effects on cellular processes such as neurite outgrowth and immune cell activation. | ||||||