Sec62 Activators
Sec62 Activators refer to a class of chemicals that can influence the activity or expression of the Sec62 protein, a component involved in the endoplasmic reticulum (ER) associated protein degradation (ERAD) pathway and ER protein import. Some of these activators exert their effects by perturbing the ER environment or influencing associated cellular pathways, indirectly impacting Sec62.
Dithiothreitol (DTT) serves as a reducing agent that disrupts disulfide bonds, causing protein misfolding within the ER. 4-Phenylbutyric acid (4-PBA) functions as a chemical chaperone that alleviates ER stress, while Guanabenz enhances the ER stress response. Ionomycin increases intracellular calcium concentrations, affecting ER stress levels. Geldanamycin acts as an Hsp90 inhibitor, influencing proteins associated with Sec62, while Celastrol induces the heat shock response, affecting ER protein homeostasis. Finally, Chloroquine alters endosomal pH, influencing protein trafficking and impacting Sec62 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $52.00 $133.00 $410.00 | 10 | |
Chemical chaperone that alleviates ER stress, potentially influencing Sec62 activity. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $100.00 $459.00 $816.00 $4080.00 $7140.00 | 2 | |
Enhances the ER stress response, which might influence Sec62 function. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Increases intracellular calcium concentrations, affecting ER stress and possibly Sec62 activity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
An Hsp90 inhibitor which might indirectly influence proteins associated with Sec62. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
An inducer of the heat shock response, it could affect ER protein homeostasis and indirectly influence Sec62. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Alters endosomal pH and can influence protein trafficking, potentially impacting Sec62 activity. | ||||||