SEC11A Inhibitors
SEC11A inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the SEC11A protease. SEC11A is a component of the signal peptidase complex (SPC), which plays a crucial role in protein processing within cellular biology. The SPC is responsible for cleaving signal peptides from nascent proteins during their translocation into the endoplasmic reticulum (ER). This cleavage is essential for proper protein folding and function as it ensures that proteins reach their destined locations within the cell or are secreted out of the cell entirely. SEC11A inhibitors, therefore, are designed to interact with the active site of the SEC11A protease or otherwise alter its function, effectively blocking the signal peptide cleavage process.
The inhibition of SEC11A can lead to an accumulation of unprocessed precursor proteins, a situation that can have various effects on cellular functions due to the disruption in the flow of proteins through the secretory pathway. By interfering with the function of SEC11A, these inhibitors can affect the maturation and stability of a wide array of proteins that require signal peptide removal for their normal operation. The development of SEC11A inhibitors is based on understanding the structure and mechanism of action of the SEC11A protease. Researchers often use techniques such as X-ray crystallography, molecular docking, and computational modeling to design molecules that can effectively bind to the active site of SEC11A or to regions that are critical for its structural integrity and catalytic activity. The specificity of these inhibitors is paramount, as off-target effects could disrupt other proteases or cellular processes, leading to an array of unintended consequences.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
A potent inhibitor of the endoplasmic reticulum-associated degradation (ERAD) pathway, Eeyarestatin I disrupts protein dislocation from the ER, consequently inhibiting SEC11A's role in the proteasomal degradation of misfolded ER proteins. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that prevents the degradation of polyubiquitinated proteins, MG-132 indirectly hampers SEC11A function by impeding the proteolytic process in which SEC11A is involved, leading to the accumulation of proteins that would otherwise be processed by the proteasome. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
An N-linked glycosylation inhibitor that causes ER stress and subsequent unfolded protein response (UPR), tunicamycin can indirectly inhibit SEC11A by disrupting normal protein folding processes in the ER, thus affecting its protease function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
A fungal metabolite that interferes with protein transport from the ER to the Golgi apparatus, Brefeldin A can indirectly affect SEC11A by altering protein trafficking and processing pathways that SEC11A is part of. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
An inhibitor of eukaryotic protein biosynthesis that prevents translation elongation, cycloheximide indirectly affects SEC11A function by reducing the overall pool of nascent proteins available for processing in the ER. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump inhibitor, thapsigargin leads to calcium depletion from the ER, indirectly affecting SEC11A by inducing ER stress and the UPR, which can alter SEC11A's protease activity. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
An irreversible inhibitor of cysteine proteases that can indirectly inhibit SEC11A by inhibiting upstream proteolytic processes that would otherwise feed substrates to the SEC11A-mediated pathway. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $65.00 $122.00 $428.00 $851.00 $1873.00 $4994.00 | 33 | |
A serine protease inhibitor that can indirectly inhibit SEC11A by blocking upstream proteolytic events, potentially reducing the flow of proteins through the pathway SEC11A is involved in. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
A selective and potent inhibitor of the proteasome beta-subunits, which indirectly impacts SEC11A's function in the degradation of proteins by inhibiting the proteasomal activity SEC11A contributes to. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $32.00 | ||
A metalloprotease inhibitor that chelates zinc, 1,10-phenanthroline could indirectly inhibit SEC11A function by inhibiting metalloproteases that participate in earlier steps of protein maturation and thus would affect the substrate availability for SEC11A. | ||||||