SCCRO Activators
SCCRO, also known as DCUN1D1, is a gene that encodes an essential protein involved in the neddylation pathway, a process that modifies other proteins to alter their function, location, or signaling pathways. As a participant in this post-translational modification system, SCCRO is important for the regulation of various cellular activities, including cell cycle progression and apoptosis. The gene's expression and the activity of its encoded protein can be influenced by a range of internal and external cellular signals, and its dysregulation has been noted in particular pathologies such as squamous cell carcinoma. Research into SCCRO is dynamic and ongoing, with studies aiming to elucidate its precise role in cell biology, as well as how it can be influenced by various molecules and environmental factors.
A number of specific chemical compounds have been identified as potential activators that could induce the expression of the SCCRO protein. These activators operate through diverse mechanisms to elevate the levels of SCCRO within cells. For instance, compounds like 5-Azacytidine and Epigallocatechin gallate are known to play a role in the epigenetic modification of DNA, which can lead to the hypomethylation of the SCCRO gene promoter and its subsequent activation. On the other hand, signaling modulators such as Phorbol 12-myristate 13-acetate and Forskolin work through activation of protein kinase pathways that can result in the upregulation of SCCRO. Additional compounds like Thapsigargin and Tunicamycin induce expression by eliciting an unfolded protein response due to stress within the endoplasmic reticulum, a situation that can also lead to increased levels of SCCRO. Understanding the influence of these activators on SCCRO expression is a complex task that involves deciphering the intricate network of cellular signaling pathways. Nonetheless, these insights contribute significantly to our fundamental understanding of cellular biology and the modulation of specific genes under various conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine may upregulate SCCRO expression by causing hypomethylation of gene promoters, thereby facilitating transcription initiation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could stimulate SCCRO gene expression through the inhibition of histone deacetylase, resulting in a more accessible chromatin structure for transcription factors. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may enhance SCCRO expression by activating nuclear receptors that bind to responsive elements in the SCCRO gene promoter region. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is known to increase SCCRO levels by activating protein kinase C, which in turn may activate transcription factors responsible for SCCRO expression. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin could induce SCCRO expression as a cellular response to the elevated cytosolic calcium levels and ensuing endoplasmic reticulum stress it causes. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin may lead to an upregulation of SCCRO as it triggers the unfolded protein response due to inhibition of N-linked glycosylation in the ER. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate can stimulate an increase in SCCRO expression through its histone deacetylase inhibitory activity, which results in a relaxed chromatin state conducive to gene transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may promote SCCRO expression by activating glycogen synthase kinase-3β (GSK-3β) inhibition, thereby stimulating the Wnt/β-catenin transcriptional pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin has the potential to increase SCCRO expression by elevating cAMP levels, which may activate protein kinase A (PKA) and subsequently the transcription factor CREB. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
2-Methoxyestradiol may stimulate SCCRO expression by disrupting microtubule dynamics, leading to cell cycle arrest and activation of stress-related signaling pathways. | ||||||