scc-112 Inhibitors
Inhibitors of SCC-112 target various aspects of the mitotic process, thereby reducing the functional activity of the protein, which is essential in maintaining chromosome cohesion and organization during cell division. Compounds that disrupt the activation of the anaphase-promoting complex/cyclosome (APC/C) by binding and inhibiting crucial regulatory proteins like Cdc20 render SCC-112 unable to fulfill its role in regulating sister chromatid cohesion, leading to cell cycle arrest. Similarly, small molecule inhibitors that affect Aurora kinases induce defects in spindle assembly and chromosome segregation, further inhibiting SCC-112 activity indirectly. These molecules, by halting the essential mitotic events where SCC-112 is a key player, lead to mitotic arrest and subsequent inhibition of SCC-112's function in chromosome alignment and segregation.
Additional classes of SCC-112 inhibitors include those that target kinesin motor proteins and spindle microtubule dynamics, which are necessary for proper spindle formation and cytokinesis. Kinesin inhibitors, such as those against kinesin Eg5 or the spindle protein KSP, prevent the separation of spindle poles or interfere with microtubule dynamics, respectively, impeding the activity of SCC-112. Moreover, inhibitors of centrosome-associated proteins and microtubule-stabilizing agents like paclitaxel also contribute to the indirect inhibition of SCC-112 by either affecting chromosome alignment or by stabilizing microtubules to a degree that prevents their proper function during mitosis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Reversine | 656820-32-5 | sc-203236 | 5 mg | $221.00 | 13 | |
Reversine is a small molecule inhibitor of Aurora kinases and A3 adenosine receptor. It disrupts mitotic spindle assembly and can lead to cell cycle arrest. By affecting the mitotic spindle formation, reversine can indirectly decrease the functional activity of scc-112, which is implicated in chromosome segregation during mitosis. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI 2536 is a potent Plk1 inhibitor that disrupts spindle formation and cytokinesis, leading to mitotic arrest. Inhibition of Plk1 ultimately impedes the function of scc-112 by disrupting the processes of chromosome alignment and segregation, where scc-112 plays a critical role in maintaining sister chromatid cohesion. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor that arrests cells in mitosis by preventing spindle pole separation. This leads to the inhibition of scc-112 function as scc-112 is required for proper chromosome alignment and segregation during mitosis, which are processes dependent on the kinesin motor activity. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor, which disrupts chromosome alignment and segregation during mitosis. By inhibiting Aurora kinase activity, it consequently inhibits scc-112 by preventing proper functioning of the cohesin complex in chromosome segregation, a process essential for mitosis and one in which scc-112 is involved. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an inhibitor of Aurora A kinase, leading to defects in centrosome separation and maturation. This results in aberrant spindle formation and mitotic arrest, thereby indirectly inhibiting the activity of scc-112, which is critical for chromosome organization and segregation during mitosis. | ||||||
Ispinesib | 336113-53-2 | sc-364747 | 10 mg | $505.00 | ||
Ispinesib is a kinesin spindle protein (KSP) inhibitor that interferes with spindle microtubule dynamics, leading to mitotic arrest. The inhibition of KSP impacts the role of scc-112 in maintaining proper chromosome cohesion and segregation during mitosis, indirectly reducing scc-112 activity. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-trityl-L-cysteine is a selective inhibitor of the kinesin Eg5, which is involved in spindle microtubule dynamics. By inhibiting Eg5, it disrupts mitotic spindle formation and arrests cells in mitosis, subsequently inhibiting scc-112 function in chromosome segregation and cohesion. | ||||||
GSK 923295 | 1088965-37-0 | sc-490136 | 5 mg | $290.00 | ||
GSK923295 is a centromere-associated protein E (CENP-E) inhibitor that disrupts mitotic progression by affecting chromosome alignment. By inhibiting CENP-E, GSK923295 indirectly inhibits scc-112 function, because scc-112 is involved in the maintenance of chromosome cohesion necessary for proper segregation in mitosis. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and prevents their disassembly, leading to mitotic arrest. This affects the function of scc-112 indirectly, as scc-112 is essential for the regulation of chromosome cohesion and segregation, processes that are disrupted when microtubule dynamics are altered by Taxol. | ||||||