SCAMP3 Inhibitors
Chemical inhibitors of SCAMP3 target various aspects of the protein's involvement in cellular transport and membrane trafficking processes. Brefeldin A inhibits the ADP-ribosylation factor (ARF), disrupting the vesicle trafficking process that SCAMP3 is part of by preventing vesicle formation and subsequent fusion with target membranes. Similarly, Monensin alters intracellular ion gradients, such as pH and sodium/calcium balance, which are crucial for SCAMP3's role in vesicle scission and fusion; this interference can impede SCAMP3-mediated transport. Disrupting the cytoskeleton affects SCAMP3's function significantly, as seen with Nocodazole and Cytochalasin D. Nocodazole's ability to depolymerize microtubules hinders SCAMP3's vesicle transport capabilities along these structures, while Cytochalasin D blocks actin polymerization, a process essential for SCAMP3's vesicle movement functions.
Furthermore, Dynasore's inhibition of the GTPase dynamin directly impacts vesicle scission, which is a critical process for SCAMP3's function in endocytosis. ML-9 affects SCAMP3 by inhibiting myosin light-chain kinase (MLCK), which is necessary for myosin motor function that SCAMP3 may utilize for vesicular transport. Paclitaxel and Colchicine exert their inhibitory effects by disrupting microtubule dynamics; Paclitaxel by stabilizing and preventing disassembly, and Colchicine by inhibiting polymerization. These alterations in microtubule stability can lead to aberrant SCAMP3-mediated vesicle dynamics. Latrunculin A and Jasplakinolide, on the other hand, modulate actin dynamics, with Latrunculin A disrupting polymerization and Jasplakinolide stabilizing filaments, both of which are detrimental to SCAMP3's dependency on the actin cytoskeletal rearrangements for its trafficking functions. Finally, Endosidin2's interference with Rab GTPases disrupts endosomal trafficking, a pathway integral to SCAMP3's function, while Tyrphostin AG1478 inhibits EGFR tyrosine kinase, which is critical for endocytic recycling, thereby also inhibiting SCAMP3's associated transport activities.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A inhibits ADP-ribosylation factor (ARF), a small GTPase involved in vesicle trafficking, which SCAMP3 is known to associate with. Inhibition of ARF can disrupt SCAMP3's role in vesicle budding and fusion, thereby inhibiting SCAMP3 function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that disrupts intracellular pH and sodium/calcium balance. SCAMP3 is involved in membrane trafficking, and disrupting these ion gradients can inhibit SCAMP3's vesicle scission and fusion activities. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization. SCAMP3 is implicated in trafficking along microtubules, and the depolymerization of microtubules can hinder SCAMP3's ability to function in vesicle transport. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D inhibits actin polymerization. Since SCAMP3 is involved in vesicular trafficking, which relies on the actin cytoskeleton, inhibiting actin filaments can impede SCAMP3-mediated vesicle movement. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a GTPase inhibitor that specifically inhibits dynamin, which mediates vesicle scission. SCAMP3 is associated with vesicle formation and release, and inhibition of dynamin can therefore inhibit SCAMP3's role in endocytosis. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9 is a kinase inhibitor that can inhibit myosin light-chain kinase (MLCK). Since SCAMP3 is involved in vesicular transport processes that can be dependent on myosin motors, ML-9 can inhibit SCAMP3's vesicle trafficking functions. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, preventing their disassembly. Because SCAMP3 is involved in vesicle trafficking along microtubules, hyperstabilization of microtubules can aberrantly inhibit SCAMP3's role in vesicle dynamics. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts actin filament polymerization. SCAMP3, which has a role in actin cytoskeleton-dependent vesicle trafficking, would be inhibited in its function due to the impairment of the actin cytoskeleton. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits its polymerization. As SCAMP3 is implicated in microtubule-based vesicle transport, colchicine's effect on microtubule dynamics can inhibit the trafficking functions of SCAMP3. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments and prevents their depolymerization. By stabilizing actin, it can perturb the dynamic rearrangements of the cytoskeleton required for SCAMP3's role in membrane trafficking and fusion events. | ||||||