SAMD4A Inhibitors
SAMD4A inhibitors constitute a diverse set of compounds that primarily target epigenetic and cellular regulatory mechanisms to modulate the expression of SAMD4A. A-366, a histone methyltransferase inhibitor, selectively targets PRC2, altering the H3K27me3 epigenetic mark and thereby indirectly influencing SAMD4A expression by reshaping the chromatin landscape associated with its regulatory regions.
In addition, JIB-04 serves as a Jumonji histone demethylase inhibitor, impacting H3K9 demethylation. This alteration in the epigenetic context indirectly modulates SAMD4A expression by introducing modifications in the chromatin environment that surrounds its genomic loci. Similarly, UNC1999, a G9a/GLP histone methyltransferase inhibitor, affects H3K9 methylation, leading to modifications in the epigenetic state and potentially influencing SAMD4A by reshaping the chromatin landscape around its regulatory regions. Furthermore, SAMD4A inhibitors extend beyond epigenetic modulators to include compounds such as 5-Azacytidine, a DNA methyltransferase inhibitor. By incorporating into DNA during replication, 5-Azacytidine alters DNA methylation patterns, indirectly impacting SAMD4A expression through epigenetic modifications in its regulatory regions. This multifaceted approach emphasizes the importance of understanding the interconnected regulatory networks influencing SAMD4A expression, offering valuable insights into the potential avenues for interventions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-366 | 1527503-11-2 | sc-507495 | 10 mg | $195.00 | ||
Histone methyltransferase inhibitor targeting PRC2. A-366 modulates the H3K27me3 epigenetic mark, indirectly influencing SAMD4A expression by altering the chromatin landscape associated with its regulatory regions. | ||||||
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
Jumonji histone demethylase inhibitor impacting H3K9 demethylation. JIB-04 alters the epigenetic context, indirectly modulating SAMD4A expression through modifications in the chromatin environment. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
G9a/GLP histone methyltransferase inhibitor affecting H3K9 methylation. UNC1999 modulates the epigenetic state, potentially influencing SAMD4A indirectly by altering the chromatin landscape around its genomic loci. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor incorporating into DNA during replication. Alters DNA methylation patterns, indirectly impacting SAMD4A expression through epigenetic modifications in its regulatory regions. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Glycolysis inhibitor disrupting glucose metabolism. Indirectly modulates SAMD4A expression by influencing energy-sensitive signaling pathways associated with its transcriptional regulation. | ||||||
(+)-Nutlin-3 | 675576-97-3 | sc-222085 sc-222085A | 500 µg 1 mg | $94.00 $122.00 | ||
MDM2 inhibitor disrupting p53 degradation. Alters p53-mediated transcriptional regulation, potentially influencing SAMD4A indirectly through downstream effects on shared regulatory pathways. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Cyclin-dependent kinase (CDK) inhibitor disrupting cell cycle progression. Alters the cell cycle-associated signaling pathways, potentially influencing SAMD4A expression indirectly through CDK-dependent regulatory mechanisms. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Histone deacetylase (HDAC) inhibitor impacting chromatin acetylation. Alters the epigenetic landscape, indirectly influencing SAMD4A expression by modulating the acetylation status of associated histones. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
G9a/GLP histone methyltransferase inhibitor affecting H3K9 methylation. Modulates the epigenetic state, potentially influencing SAMD4A indirectly by altering the chromatin landscape around its genomic loci. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
TGF-β receptor inhibitor disrupting TGF-β signaling. Modulates downstream events, potentially influencing SAMD4A expression indirectly through alterations in the TGF-β-dependent regulatory network. | ||||||