S2P Activators

The class of chemicals known as S2P Activators encompasses a diverse set of compounds that can influence the activity of MBTPS2, also known as S2P, a membrane-bound zinc metalloprotease.

Thapsigargin and A23187 are compounds that elevate intracellular calcium levels. The shifts in calcium dynamics within the cell can subsequently influence signaling pathways where S2P plays a role. Tunicamycin acts by inhibiting N-linked glycosylation, a process that could modulate the activity or stability of S2P by affecting its post-translational modifications. Brefeldin A, on the other hand, disrupts the structure and function of the Golgi apparatus, a cellular location where S2P processing or activity may be significant. Another chemical, Phenylarsine oxide, obstructs protein transport between the endoplasmic reticulum and Golgi, which can have implications for the activity and function of S2P. Cerulenin's ability to inhibit lipid synthesis and the ionophores like Monensin and Nigericin, which disrupt cellular ion balance, serve as another layer of influence over processes related to S2P. FCCP, by uncoupling mitochondrial oxidative phosphorylation, alters cellular energetics that can indirectly influence S2P's role within the cell. Lastly, Progesterone, a steroid hormone, has the capability to regulate a broad spectrum of cellular pathways and can indirectly touch upon the functions or regulatory mechanisms tied to S2P.