S-100Z Inhibitors
The efficacy of S-100Z inhibitors is predominantly tied to their action on calcium signaling and homeostasis, a critical factor for S-100Z's functional role as a calcium-binding protein. Agents that block calcium channels effectively reduce the influx of calcium ions into the cell, thus curtailing the availability of calcium necessary for S-100Z to perform its cellular duties. Specifically, these blockers target voltage-gated channels and are selective for subtypes most relevant to S-100Z's modus operandi, thereby directly impinging on its ability to act as a signal transducer and modulator within the cell. Additionally, certain calcium chelators operate intracellularly to sequester free calcium, disrupting the delicate balance required for S-100Z's activation and its subsequent involvement in signaling cascades.
Furthermore, a subset of these inhibitors encompasses molecules that target calcium-dependent enzymes and proteins, such as protein kinase C and calmodulin. By impeding the function of these entities, the inhibitors indirectly thwart the signaling pathways that S-100Z is part of, leading to a reduction in its activity. A prime illustration is the inhibition of the calcium/calmodulin-dependent protein kinase, which is essential for the transduction of calcium signals that S-100Z could influence. Additionally, agents that inhibit the release of calcium from internal stores, such as the sarcoplasmic reticulum, also play a role in diminishing the functionality of S-100Z.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
This calcium channel blocker prevents calcium ions from entering cells, which is crucial for the S-100Z protein as it binds calcium for its functioning. With reduced cytosolic calcium, S-100Z's activity as a calcium sensor and signal transducer is diminished. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
A potent inhibitor of protein kinase C (PKC), which is involved in calcium-mediated signal transduction. Inhibition of PKC can downregulate signaling pathways that are vital for S-100Z function in cells. | ||||||
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $56.00 $99.00 | 9 | |
Functions as a calmodulin antagonist, thereby inhibiting calcium-calmodulin dependent processes. Since S-100Z is also a calcium-binding protein, interference with calcium signaling can impede S-100Z's role in cellular processes. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
As an inhibitor of calmodulin, this compound disrupts calcium-dependent signal transduction that could implicate the functional activity of S-100Z as it may be involved in similar pathways. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
A cell-permeable calcium chelator that buffers intracellular calcium levels, potentially impairing the ability of S-100Z to bind calcium and thus inhibiting its activity. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
This compound inhibits calcium/calmodulin-dependent protein kinase II (CaMKII), an enzyme that transduces calcium signals. Inhibition of CaMKII may indirectly prevent S-100Z from fulfilling its role in calcium signaling cascades. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
An inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to depletion of calcium stores and thus potentially restricting S-100Z's calcium-dependent activities. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $60.00 $301.00 | 2 | |
This selective calcium channel blocker preferentially affects voltage-gated L-type calcium channels. By reducing calcium influx, it can indirectly inhibit S-100Z activity which depends on intracellular calcium levels. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Inhibits calcineurin, a calcium/calmodulin-dependent phosphatase. By inhibiting this signaling enzyme, downstream effects on proteins like S-100Z, which rely on calcium-mediated signals, are expected. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $89.00 $218.00 | 1 | |
As a calcium channel antagonist, it limits the entry of calcium into cells, which can indirectly result in the inhibition of S-100Z’s activity due to its reliance on intracellular calcium levels. | ||||||