RNF113A Activators
RNF113A activators engage in various cellular mechanisms to enhance the protein's functional role in the cell. The activation process often involves the modulation of signaling pathways that lead to increased phosphorylation of the protein. For instance, some compounds directly elevate intracellular cyclic AMP levels, which then activate protein kinase A (PKA). PKA is known to phosphorylate various proteins; such phosphorylation events can enhance the activity of RNF113A by promoting its interaction with other molecular players within the cell. Additionally, other molecules can raise intracellular calcium levels, which in turn activates calcium-dependent kinases that may target RNF113A for phosphorylation. By increasing the phosphorylation state of RNF113A, these calcium ionophores ensure that RNF113A is in a prime state for exerting its functions, which can include DNA repair, transcriptional control, and other pivotal cellular processes.
Furthermore, certain activators work by inhibiting phosphatase activity within the cell, leading to a general increase in protein phosphorylation. This inhibition can indirectly result in the enhanced phosphorylation and activation of RNF113A. Other activators may stimulate protein kinase C (PKC) or stress-activated protein kinases such as JNK, which then phosphorylate various substrates that may include RNF113A as part of the cellular response to environmental cues. Additionally, some compounds are known to inhibit enzymes like glycogen synthase kinase-3 (GSK-3), which could alter the phosphorylation landscape of the cell and potentially favor the activation state of RNF113A.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
A potent activator of adenylyl cyclase, which increases cyclic AMP (cAMP) levels within cells. Elevated cAMP levels can enhance the phosphorylation states of various proteins, including RNF113A, leading to its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cell-permeable cAMP analog that mimics the action of endogenous cAMP by activating protein kinase A (PKA). PKA can then phosphorylate and activate proteins downstream, including RNF113A. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that raises intracellular calcium levels, which can activate calcium-dependent kinases such as calmodulin-dependent kinase (CaMK), potentially leading to the phosphorylation and activation of RNF113A. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
An activator of protein kinase C (PKC) that can modulate the phosphorylation status of various proteins. PKC-mediated phosphorylation may lead to the activation of RNF113A. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
An inhibitor of phosphatases, which can lead to an increase in the phosphorylation state of proteins by preventing dephosphorylation. This may result in the indirect activation of RNF113A. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent phosphatase inhibitor that, like sodium fluoride, can lead to increased phosphorylation levels of proteins by inhibiting their dephosphorylation. This can indirectly lead to the activation of RNF113A. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
A phosphatase inhibitor that can lead to an increase in the phosphorylation state of proteins, which could include RNF113A, leading to its functional activation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
A cyclin-dependent kinase (CDK) inhibitor that might lead to the activation of alternative pathways or proteins as a compensatory response, which could include the activation of RNF113A. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
An inhibitor of phosphodiesterase type 5 (PDE5), leading to an increase in cAMP and/or cGMP levels, potentially activating PKA or PKG, which may then phosphorylate and activate RNF113A. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A synthetic catecholamine acting as an agonist of beta-adrenergic receptors, leading to increased production of cAMP and activation of PKA, which could then lead to phosphorylation and activation of RNF113A. | ||||||