RGPD3 Inhibitors
Chemical inhibitors of RGPD3 can affect the protein's function through various mechanisms related to the disruption of microtubule dynamics. Paclitaxel stabilizes microtubules, preventing their disassembly, which is crucial for cell division and replication. This stabilization can interfere with the mitotic spindle, an essential cellular structure for chromosome separation during cell division, potentially inhibiting RGPD3 by disrupting the cell cycle. Colchicine, by binding to tubulin, inhibits its polymerization and consequently impedes cellular processes that depend on microtubule dynamics, thereby affecting RGPD3's function within those processes. Vincristine and vinblastine also bind to tubulin dimers, inhibiting microtubule assembly and leading to cell cycle arrest, which can directly inhibit the function of RGPD3 by halting progression through the cell cycle and preventing cell division.
Podophyllotoxin, eribulin, and nocodazole exhibit their inhibitory effects by binding to tubulin and either inhibiting its assembly or causing depolymerization of microtubules, leading to cell cycle arrest. These actions disrupt cellular processes that RGPD3 is implicated in, such as cell division and signal transduction pathways, and thereby can inhibit the function of RGPD3. Similarly, griseofulvin disrupts microtubule function by interfering with microtubule dynamics, which can inhibit RGPD3 activity. Thiabendazole, albendazole, and mebendazole inhibit the polymerization of microtubules, affecting cell division and signaling pathways, which in turn can inhibit RGPD3 function. Noscapine, while not directly inhibiting the polymerization of microtubules, binds to tubulin to alter its conformation, thereby affecting the microtubule network and potentially influencing RGPD3's activity within the cell by altering the processes that depend on intact microtubule functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and thereby inhibits their disassembly, which is essential for cell division and replication. By stabilizing microtubules, it can interfere with the mitotic spindle, a critical cellular structure for chromosome separation during cell division. As RGPD3 has been implicated in cell cycle regulation, paclitaxel can inhibit RGPD3 function by disrupting the cell cycle. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, one of the main constituents of microtubules, preventing its polymerization. By disrupting microtubule formation, colchicine can impede cellular processes that are dependent on microtubule dynamics, including those that RGPD3 may be involved in, leading to the inhibition of RGPD3 activity by preventing proper cellular functioning and signaling. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine interferes with microtubule assembly by binding to tubulin, which can lead to cell cycle arrest at the metaphase. This disruption can inhibit RGPD3 activity by blocking the cellular functions that RGPD3 is involved with, specifically cell division and signaling pathways that are dependent on an intact microtubule network. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin inhibits microtubule assembly by binding to tubulin, which can prevent cell division. This compound can inhibit RGPD3 by disrupting cellular processes that RGPD3 is implicated in, which are crucial for cell cycle progression. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase and sequesters tubulin into nonproductive aggregates. Eribulin's action on microtubules can inhibit RGPD3 activity by disrupting cellular processes vital for cell division and signal transduction pathways, both of which are potential functions of RGPD3. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a synthetic compound that disrupts microtubule dynamics by depolymerizing microtubules. This leads to cell cycle arrest and can inhibit RGPD3 function by interfering with cellular functions that require an intact microtubule network, which are essential for the processes that RGPD3 is believed to be involved in. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to polymerized microtubules and interfering with microtubule-associated protein-dependent microtubule dynamics. This can inhibit RGPD3 activity since RGPD3 is thought to be involved in cell cycle regulation, which requires functional microtubules. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $31.00 $82.00 $179.00 $306.00 $561.00 | 5 | |
Thiabendazole inhibits microtubule polymerization, which can result in the inhibition of cell division. By preventing proper microtubule formation, thiabendazole can inhibit RGPD3 function as it disrupts processes such as cell signaling and division, where RGPD3 is potentially involved. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $209.00 | 1 | |
Albendazole causes degenerative alterations in the intestinal cells of helminths by binding to the colchicine-sensitive site of tubulin, inhibiting its polymerization or assembly into microtubules. By affecting microtubule structure and function, albendazole can inhibit RGPD3 function by impairing cellular division and signaling pathways related to RGPD3 activity. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $45.00 $87.00 | 2 | |
Mebendazole disrupts microtubular structures within cells, which inhibits their assembly and function. This disruption can lead to inhibition of RGPD3 by affecting cellular processes that rely on microtubule integrity and function, which are essential for the biological roles that RGPD3 is known to play. | ||||||