RDM1 Inhibitors

RDM1 inhibitors 5-Azacytidine and Trichostatin A target the epigenetic machinery, potentially altering the expression of genes that control the synthesis and function of RDM1. Methyl methanesulfonate and Etoposide exert their effects through the induction of DNA damage, which can perturb DNA repair pathways that involve RDM1.

Caffeine and Olaparib target specific kinases and enzymes like PARP, which are crucial components of the DNA damage response, a process where RDM1 has a role. Similarly, KU-55933, VE-821, and NU7441 inhibit ATM, ATR, and DNA-PK kinases, respectively, which are pivotal in the signaling cascade of DNA repair mechanisms. Wortmannin's broad inhibition of PI3 kinases can affect signaling pathways that are connected to the cellular processes in which RDM1 is a participant. Additionally, SP600125 and UCN-01 are inhibitors of the JNK signaling pathway and multiple protein kinases, respectively, which can modulate signal transduction pathways and potentially influence RDM1's activity or expression.