RCC2 Inhibitors

RCC2 inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of the Regulator of Chromosome Condensation 2 (RCC2) protein. RCC2, also known as TD-60, is a multifunctional protein that plays a crucial role in various cellular processes, primarily associated with the regulation of chromosome condensation, segregation, and mitotic progression. RCC2 serves as a guanine nucleotide exchange factor (GEF) for the small GTPase Ran, participating in the nucleocytoplasmic transport of macromolecules through nuclear pore complexes. It also influences mitotic spindle assembly and cell cycle progression. RCC2 inhibitors are essential tools in molecular and cell biology research, enabling scientists to probe the functions of RCC2 and its involvement in critical cellular processes.

Researchers employ RCC2 inhibitors to investigate the specific roles of RCC2 in chromosome condensation, mitotic spindle assembly, and nucleocytoplasmic transport. By selectively inhibiting RCC2, scientists can explore its interactions with Ran GTPase and other regulatory proteins, as well as its contributions to the dynamic events of mitosis, including chromosome alignment, segregation, and cytokinesis. This research provides insights into the molecular mechanisms underlying cell division and nuclear transport, contributing to our understanding of fundamental cellular processes and their relevance to various physiological contexts. Additionally, the study of RCC2 inhibitors has broader implications for deciphering the intricate network of cell cycle regulation and the coordination of cellular events that ensure the fidelity of chromosome segregation and the maintenance of genome stability. In summary, RCC2 inhibitors serve as indispensable tools for advancing our understanding of RCC2's multifaceted roles in cellular biology, shedding light on its involvement in chromosome dynamics, mitosis, and nucleocytoplasmic transport.