RAET1G Inhibitors
RAET1G inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of the RAET1G protein. RAET1G, also known as retinoic acid early transcript 1G, is a transmembrane protein that plays a crucial role in immune regulation. It is primarily expressed on the surface of certain cells, particularly those involved in the immune response, such as dendritic cells and activated T cells. The RAET1G protein is recognized for its ability to interact with natural killer (NK) cells and regulate their activity. NK cells are integral components of the innate immune system, responsible for detecting and eliminating abnormal cells, including infected or cancerous cells.
Inhibitors targeting RAET1G function by binding to specific sites on the protein, thereby modulating its activity and subsequent interactions with NK cells. By manipulating the RAET1G pathway, these inhibitors aim to influence the immune response and cellular recognition processes. The rational design of RAET1G inhibitors involves a detailed understanding of the protein's structure and its role in immune signaling. Researchers in the field of immunopharmacology are actively exploring the potential of RAET1G inhibitors as tools to elucidate immune system functions and unravel the intricate dynamics of cellular communication. The development of such inhibitors contributes to advancing our knowledge of immune responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and prevents RNA synthesis, which could globally reduce mRNA levels, including that of RAET1G. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein elongation, potentially affecting RAET1G protein levels. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, which is necessary for DNA replication and transcription, possibly leading to reduced RAET1G expression. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is a DNA crosslinker that can inhibit DNA synthesis and transcription, potentially decreasing RAET1G expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the proteasome, which can lead to altered regulation of transcription factors and could affect RAET1G expression indirectly. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $270.00 $465.00 $1607.00 $2448.00 $5239.00 | 4 | |
Rocaglamide has been shown to inhibit translation initiation, which could decrease protein levels of targets such as RAET1G. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to DNA and inhibits RNA polymerase, which could reduce the expression of RAET1G. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can raise the pH of endosomes and lysosomes, potentially affecting the degradation of mRNA and impacting RAET1G expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 inhibits BET bromodomain proteins, which are important for the regulation of gene expression, potentially affecting RAET1G levels. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-amanitin is a potent inhibitor of RNA polymerase II and III, which could strongly inhibit transcription, including that of RAET1G. | ||||||