Rab 5B Inhibitors
Rab5B, a small GTPase, intricately regulates endocytic pathways and membrane trafficking within the cellular milieu. Despite the absence of well-established specific inhibitors for Rab5B, a strategic approach involves targeting interconnected pathways and cellular processes to indirectly modulate its function. In this context, compounds such as EHop-016, Bafilomycin A1, and Wortmannin emerge as candidates capable of influencing Rab5B-mediated processes by perturbing signaling cascades associated with endocytosis and membrane dynamics. EHop-016, known for its selectivity towards Rac1, a GTPase involved in cytoskeletal dynamics and membrane trafficking, may indirectly impact Rab5B by altering the intricate balance of cellular processes. Similarly, Bafilomycin A1 disrupts vacuolar ATPases, affecting lysosomal acidification and influencing endocytic pathways, wherein Rab5B plays a pivotal role. Additionally, Wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, can disturb Rab5B-mediated processes by interfering with PI3K-dependent signaling, showcasing the interconnectedness of pathways in cellular regulation.
The intricate dance of Rab5B with molecules like Rac1, Cdc42, and PI3K further allows for the identification of inhibitors capable of indirectly modulating Rab5B. These compounds act as disruptors of key cellular processes, including cytoskeletal dynamics and vesicle trafficking, thereby exerting a regulatory influence on Rab5B-associated functions. Rac1, Cdc42, and PI3K are integral players in cellular dynamics, and their inhibition resonates through the intricate network of cellular activities where Rab5B operates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $78.00 | ||
EHop-016 is a Rac1-specific inhibitor that could potentially influence Rab5B indirectly. Rac1 is involved in cytoskeletal dynamics and membrane trafficking, and its inhibition might affect the regulatory pathways connected to Rab5B. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
Manumycin A is a farnesyltransferase inhibitor that may indirectly modulate Rab5B. By inhibiting farnesylation, it can disrupt the localization and function of farnesylated proteins, potentially impacting Rab5B-mediated cellular processes. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 inhibits vacuolar ATPases, disrupting lysosomal acidification. This may affect endocytic pathways and Rab5B-associated processes, as Rab5B is involved in early endosome formation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor. As Rab5B function is linked to PI3K signaling, Wortmannin may impact Rab5B-mediated processes by interfering with PI3K-dependent pathways. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a dynamin inhibitor that could influence Rab5B indirectly by affecting endocytic processes. Rab5B plays a role in endocytic trafficking, and dynamin is crucial for vesicle scission during endocytosis. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $229.00 | 29 | |
Latrunculin B disrupts actin polymerization. As Rab5B is associated with membrane dynamics and vesicle trafficking, the disruption of actin cytoskeleton by Latrunculin B may indirectly affect Rab5B-mediated processes. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a Cdc42-specific small molecule inhibitor. Cdc42 is involved in cytoskeletal organization and membrane trafficking. Inhibiting Cdc42 might impact cellular processes connected to Rab5B. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, and its impact on the PI3K/Akt pathway might indirectly influence Rab5B. Rab5B is implicated in the regulation of endocytic trafficking, which can be modulated by the PI3K pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, components of the MAPK pathway. As Rab5B is associated with MAPK signaling, inhibiting MEK1/2 with U0126 may impact Rab5B-mediated cellular processes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is an antimalarial drug that affects lysosomal function by altering pH. As Rab5B is involved in endosomal trafficking and maturation, chloroquine may indirectly influence Rab5B by disrupting the acidic environment of endosomes. | ||||||