Manumycin A CAS: 52665-74-4
MF: C31H38N2O7
MW: 550.7
An antibiotic that acts as a selective and vigorous inhibitor of Ras farnesyltransferase.

Manumycin A (CAS 52665-74-4)

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应用; An antibiotic that acts as a selective and vigorous inhibitor of Ras farnesyltransferase
CAS号码: 52665-74-4
纯度: ≥96%
分子量: 550.7
分子式: C31H38N2O7
* 参考分析证明 大量特定数据 (包括水 含量).
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Manumycin A is an antibiotic originally generated by Streptomyces parvulus that acts as a selective and vigorous inhibitor of Ras farnesyltransferase. The compound has been observed to block the activity of IKKβ by robustly and rapidly inhibiting TNF alpha induced phosphorylation of IκBα and NF-κB nuclear translocation. Studies indicate that Manumycin A has the ability to induce the dimerization of IKKβ and dissociation of IKK from IKKγ/NEMO, the adapter protein. Atherosclerosis studies report that Manumycin A decreases oxidative stress. Additionally, Manumycin A irreversibly inhibits neutral sphingomyelina, and has been shown to produce nitric oxide and induce apoptosis in leukemia cell studies. Manumycin A is an inhibitor of Farnesyl Transferase and N-SMase.


参考文献

1. Hara, M., et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 2281-2285. PMID: 8460134
2. Zou, Y., et al. 1996. J. Biol. Chem. 271: 33592-33597. PMID: 8969227
3. Arenz, C., et al. 2001. Chembiochem. 2: 141-143. PMID: 11828438
4. She, M., et al. 2005. Leukemia. 19: 595-602. PMID: 15744347
5. Bernier, M., et al. 2006. J. Biol. Chem. 281: 2551-2561. PMID: 16319058
6. Sugita, M., et al. 2007. Arterioscler. Thromb. Vasc. Biol. 27: 1390-1395. PMID: 17363690

物理状态 :
Solid
溶解度 :
Soluble in ethanol (5 mg/ml), DMSO (10 mg/ml), DMF (20 mg/ml), 1:1 DMF:PBS (pH 7.2) (0.5 mg/ml), CHCl3, and MeOH. Insoluble in water.
保存 :
Store at -20° C
沸点 :
~863.6° C at 760 mmHg (Predicted)
密度 :
~1.3 g/cm3 (Predicted)
折射率 :
n20D 1.60
IC50 :
GGTase I: IC50 = 180 µM; FTase: IC50 = 5 µM
Ki 数据 :
FPP: Ki= 1.2 µM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
6438330
MDL 号码 :
MFCD00920782
SMILES :
CCCC[[email protected]@H](C)/C=C(\\C)/C=C(\\C)/C(=O)NC1=C[[email protected]]([[email protected]]2[[email protected]@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O

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引用1 - 33

PMID: # 11044431  Marra, DE. et al. 2000. Circulation. 102: 2124-2130.

PMID: # 8460134  Hara, M. et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 2281-2285.

PMID: # 28036370  PLoS Pathog. 12: e1006139.

引用1 - 33
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