PRP8 Inhibitors

The chemical class of PRP8 Inhibitors comprises compounds that indirectly influence the function of PRP8 by targeting the spliceosome and its associated processes. These inhibitors are not direct antagonists of PRP8; instead, they modulate the splicing process in which PRP8 plays a key role.Compounds like Pladienolide B, Sudemycin D6, Isoginkgetin, and Meayamycin bind to or affect the spliceosome, a complex essential for RNA splicing. By targeting the spliceosome, these compounds can disrupt the normal function of PRP8 in the splicing process. Herboxidiene, E7107, Madrasin, and Pladienolide D are also known to influence spliceosome dynamics, which can impact the role of PRP8 in RNA processing.

Additionally, compounds like FD-895, Spliceostatin A, Thailanstatin A, and FR901464 interact with various components of the spliceosome, potentially affecting the assembly and function of this complex. These interactions can lead to alterations in RNA splicing and processing, thereby influencing the activity of PRP8.