Date published: 2025-10-25

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PRAMEF9 Inhibitors

PRAMEF9 inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of PRAMEF9, a member of the Preferentially Expressed Antigen in Melanoma Family (PRAME). PRAMEF9, like other PRAME family proteins, is believed to play a role in regulating gene expression by interacting with transcriptional machinery and influencing various cellular processes such as cell growth, proliferation, differentiation, and apoptosis. Although the precise function of PRAMEF9 has not been fully characterized, it is likely involved in modulating transcriptional programs that control gene expression in response to environmental signals, developmental cues, and stress conditions. PRAME family proteins often interact with transcriptional repressors or co-activators, and by inhibiting PRAMEF9, researchers can explore its role in gene regulation and cellular homeostasis.

In research, PRAMEF9 inhibitors serve as powerful tools to investigate the molecular mechanisms underlying transcriptional regulation and how PRAMEF9 impacts cellular function. By blocking PRAMEF9 activity, scientists can study how its inhibition alters gene expression patterns, providing insights into how PRAMEF9 contributes to the control of key processes such as cell cycle regulation and cellular differentiation. This inhibition also allows for the exploration of the downstream effects on critical signaling pathways and protein networks that are influenced by PRAMEF9-mediated transcriptional activity. Additionally, PRAMEF9 inhibitors offer a unique opportunity to examine how this protein interacts with other PRAME family members or transcriptional complexes, shedding light on the broader regulatory networks that influence gene expression and cellular function. Through these studies, the use of PRAMEF9 inhibitors enhances our understanding of transcriptional control mechanisms, PRAME family functions, and the complex biological processes that regulate cellular growth and adaptation to changing environmental or physiological conditions.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

May demethylate promoter regions upstream of PRAMEF9 leading to its transcriptional silencing through changes in chromatin accessibility.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$214.00
$316.00
$418.00
7
(1)

Could target DNA methyltransferases, potentially resulting in decreased methylation and subsequent silencing of PRAMEF9 gene transcription.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$130.00
$270.00
37
(2)

Might hyperacetylate histones around the PRAMEF9 locus, leading to chromatin remodeling and a subsequent decrease in PRAMEF9 mRNA synthesis.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Could lead to the accumulation of acetylated histones, potentially repressing transcriptional initiation at the PRAMEF9 gene.

RG 108

48208-26-0sc-204235
sc-204235A
10 mg
50 mg
$128.00
$505.00
2
(1)

May directly inhibit DNA methyltransferase activity, resulting in reduced PRAMEF9 expression due to hypomethylation of its promoter region.

MS-275

209783-80-2sc-279455
sc-279455A
sc-279455B
1 mg
5 mg
25 mg
$24.00
$88.00
$208.00
24
(2)

Might selectively inhibit class I histone deacetylases, leading to a downregulation of PRAMEF9 through altered gene expression patterns.

Panobinostat

404950-80-7sc-208148
10 mg
$196.00
9
(1)

Could non-selectively inhibit histone deacetylases, leading to widespread changes in gene expression including a potential reduction in PRAMEF9 levels.

Mithramycin A

18378-89-7sc-200909
1 mg
$54.00
6
(1)

May bind to specific DNA sequences within the PRAMEF9 promoter and directly inhibit its transcriptional activity.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Could bind tightly to DNA sequences, particularly at transcription initiation complexes, and inhibit PRAMEF9 mRNA elongation.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$226.00
$846.00
1
(0)

Might disrupt the binding of bromodomain-containing proteins to acetylated histones, leading to transcriptional repression of PRAMEF9.