PRAMEF4 inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of PRAMEF4, a member of the Preferentially Expressed Antigen in Melanoma Family (PRAME). PRAMEF4, like other members of the PRAME family, is involved in regulating gene expression, particularly through interactions with transcriptional complexes that control various cellular processes such as growth, proliferation, and differentiation. Though the precise biological role of PRAMEF4 is not fully characterized, its function is believed to be tied to modulating the activity of genes that are crucial for maintaining cellular homeostasis and responding to environmental cues. By inhibiting PRAMEF4, researchers can investigate how this protein contributes to transcriptional regulation, helping to unravel its role in critical processes like cell cycle progression and cellular signaling pathways.
In research settings, PRAMEF4 inhibitors are useful tools for exploring the molecular mechanisms by which PRAMEF4 influences gene expression and cellular dynamics. By blocking PRAMEF4 activity, scientists can study the downstream effects on transcriptional regulation, including changes in the expression of specific genes and the broader impact on cellular behavior. This inhibition allows researchers to delve into how PRAMEF4 may control gene sets associated with cell proliferation or differentiation and its involvement in maintaining cellular responses to growth signals or stress. Additionally, PRAMEF4 inhibitors provide insight into the interactions between PRAMEF4 and other proteins involved in transcriptional regulation, as well as its relationship with other PRAME family members. These studies enhance our understanding of the regulatory networks that govern gene expression and highlight the broader implications of PRAMEF4 in cellular function and adaptive responses to changing environmental or developmental conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could hypothetically disrupt the methylation pattern of the PRAMEF4 gene promoter, leading to a subsequent reduction in its expression levels. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
By inhibiting the enzymatic activity that adds methyl groups to the DNA associated with PRAMEF4, 5-Aza-2′-Deoxycytidine could decrease PRAMEF4 transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid may lead to the accumulation of acetylated histones in the chromatin surrounding the PRAMEF4 gene, potentially causing a downregulation in its mRNA synthesis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could promote hyperacetylation of histones at the PRAMEF4 locus, leading to a closed chromatin state and decreased gene expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram may inhibit the transcription factor(s) directly involved in the upregulation of PRAMEF4, leading to diminished gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid might bind to retinoid receptors that interact with the PRAMEF4 promoter, leading to transcriptional repression of this gene. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein could interfere with specific kinase pathways that are necessary for the transcriptional initiation of PRAMEF4, resulting in reduced expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may repress the transcriptional activators required for PRAMEF4 gene expression, leading to a decrease in its mRNA levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could downregulate PRAMEF4 expression by inhibiting the release of transcriptional coactivators necessary for its gene transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate may induce histone hyperacetylation at the PRAMEF4 gene locus, which could lead to transcriptional repression of the gene. | ||||||