PRAMEF24 Inhibitors
PRAMEF24 inhibitors are a class of small molecules or compounds that specifically target the PRAME (Preferentially Expressed Antigen in Melanoma) F24 protein, a member of the larger PRAME family of proteins. These proteins belong to the cancer-testis antigen family and are involved in several biological processes, including cellular differentiation and proliferation. PRAMEF24 itself is an isoform that shares a high degree of homology with other members of the PRAME family. In the context of biochemical pathways, PRAMEF24 plays a regulatory role, potentially influencing gene expression by interacting with nuclear receptor pathways. Its activity is closely linked to transcriptional repression, where it modulates specific promoter regions by recruiting corepressor complexes or histone-modifying enzymes.
The structural basis of PRAMEF24 inhibitors involves the recognition of distinct domains or motifs within the protein that are essential for its function. These inhibitors can interact with the protein's binding sites, altering its conformational state and preventing it from engaging in its normal interactions within the cell. By binding to the PRAMEF24 protein, these inhibitors disrupt key protein-protein interactions or hinder the recruitment of transcriptional machinery, effectively modifying the biological outcomes associated with PRAMEF24 signaling. The design and synthesis of PRAMEF24 inhibitors require a detailed understanding of its three-dimensional structure, often aided by techniques such as X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy. These inhibitors provide valuable tools for probing the precise molecular roles of PRAMEF24 in various cellular contexts and are crucial for advancing the understanding of this protein's contributions to fundamental biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid is a histone deacetylase inhibitor that could potentially lead to a more condensed chromatin state around the PRAMEF24 gene, thereby decreasing its transcriptional activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
By inhibiting DNA methyltransferase, 5-Aza-2′-Deoxycytidine may induce hypomethylation of the PRAMEF24 gene promoter, which could result in reduced expression if this region is subject to gene silencing via hypermethylation. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram has been shown to inhibit the NF-κB pathway, which could lead to a decrease in the expression of PRAMEF24 if it is under the control of NF-κB responsive elements. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could downregulate PRAMEF24 by binding to retinoic acid receptors that may repress the transcription of genes involved in cell proliferation, including potentially PRAMEF24. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is often involved in the translation of proteins necessary for cell growth and proliferation; this could result in a decreased expression of PRAMEF24 if it is downstream of mTOR signaling. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 inhibits BET bromodomain-containing proteins, potentially leading to the displacement of transcriptional machinery from promoter regions and a consequent decrease in PRAMEF24 transcription. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to DNA and preferentially intercalates at GC-rich sequences, which could inhibit the binding of transcriptional activators to the PRAMEF24 promoter, leading to decreased gene expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide has been shown to inhibit the transcriptional activity of certain genes by downregulating RNA polymerase II activity, which could reduce the expression of PRAMEF24 if it is a target of this transcriptional repression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib causes the buildup of ubiquitinated proteins, potentially leading to the activation of cellular stress pathways that may downregulate the transcription of genes like PRAMEF24. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 disrupts the interaction between p53 and MDM2, enhancing p53 stability and activity, which might lead to the transcriptional repression of PRAMEF24 if it is negatively regulated by p53. | ||||||