PRAMEF18 inhibitors constitute a distinct chemical class designed to modulate the activity of the PRAMEF18 protein. PRAMEF18, a member of the PRAME (preferentially expressed antigen in melanoma) family, is associated with various cellular processes, including gene regulation and modulation of immune responses. Inhibitors targeting PRAMEF18 operate by disrupting its normal functions within these pathways, thereby influencing the intricate molecular processes that involve this protein. PRAMEF18 inhibitors exert their effects by interfering with the molecular interactions and signaling cascades associated with PRAMEF18, potentially leading to altered gene expression patterns and modulation of immune responses.
The specific mechanism of action of PRAMEF18 inhibitors is centered around the disruption of molecular pathways where PRAMEF18 plays a crucial role. By perturbing these pathways, these inhibitors can potentially influence cellular processes regulated by PRAMEF18, providing researchers with valuable tools to explore the intricate molecular networks associated with gene expression and immune modulation. Understanding the role of PRAMEF18 and the impact of its inhibition contributes to the broader knowledge of cellular biology, offering insights into the intricate molecular processes involved in gene regulation and immune responses. PRAMEF18 inhibitors serve as crucial instruments in deciphering the molecular intricacies of these pathways and expanding our comprehension of the biological factors influencing cellular behavior.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine causes demethylation of DNA, potentially reversing epigenetic silencing and affecting gene expression, including possibly reducing PRAMEF18 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor, leading to DNA demethylation and potentially altering the expression of various genes including PRAMEF18. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylase, causing changes in chromatin structure and potentially downregulating genes like PRAMEF18. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, another histone deacetylase inhibitor, could affect gene expression patterns, potentially including PRAMEF18. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat, a class I histone deacetylase inhibitor, may change the expression of certain genes, which could include PRAMEF18. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is a histone deacetylase inhibitor that can modify the expression of various genes, potentially including PRAMEF18. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor that does not incorporate into DNA but can still potentially influence gene expression, including PRAMEF18. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to DNA and inhibits RNA polymerase, which could reduce the expression of PRAMEF18. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can modulate NF-kB activity and may have off-target effects that alter gene expression, including potential reduction of PRAMEF18 expression. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide can inhibit NF-kB signaling, which might result in the decreased expression of certain genes, possibly including PRAMEF18. | ||||||