PPAN Inhibitors

PPAN, also known as Peter Pan, has roles integral to various phases of cellular growth, including larval growth, mitotic growth, oogenesis progression, and maturation of specific imaginal tissues. PPAN inhibitors can influence these pathways, either directly or indirectly. For instance, agents such as paclitaxel and colchicine can stabilize or disrupt microtubules, respectively. This can impact cell division, an essential component of mitotic growth. CDK inhibitors like Olomoucine II and Roscovitine are known to affect cell cycle progression, given that CDKs are crucial to different phases of the cell cycle.

PPAN's role in growth indicates that any perturbation in the cell cycle might influence its functions. Aurora kinase and Plk1 inhibitors, such as ZM 447439 and BI 2536 respectively, target proteins vital for mitotic progression. The interconnectedness of cell cycle proteins and the described functions of PPAN mean that agents affecting these proteins can also impact PPAN's functions. In essence, the selected inhibitors either play a direct role in pathways where PPAN is a component or can indirectly influence processes where PPAN is fundamental.