PP2A-B72/B130 Activators
PP2A-B72/B130 Activators are a class of chemical compounds that play a crucial role in cellular signaling pathways and the regulation of various cellular processes. These activators are specifically designed to interact with and modulate the activity of the protein phosphatase 2A (PP2A), which is a key enzyme involved in the dephosphorylation of proteins. PP2A-B72/B130 Activators are essential for maintaining the balance between phosphorylation and dephosphorylation events within cells, ultimately influencing cell function and behavior.
PP2A, composed of a catalytic subunit (C), a scaffolding subunit (A), and a regulatory subunit (B), is a heterotrimeric serine/threonine phosphatase known for its critical role in regulating the phosphorylation status of various proteins. The B subunits, including B72 and B130, are responsible for directing the enzyme to specific substrates and cellular locations. PP2A-B72/B130 Activators act as small molecules or compounds that bind to the regulatory B subunits of PP2A, leading to the activation of the phosphatase enzyme. This activation, in turn, results in the dephosphorylation of target proteins, affecting their activity and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels which enhance PP2A-B72/B130 activity by promoting the assembly of the PP2A holoenzyme complex. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $77.00 $316.00 | 12 | |
Ceramide activates protein phosphatase 2A (PP2A), and since PP2A-B72/B130 is a regulatory subunit of PP2A, ceramide can enhance its activity by stabilizing the PP2A complex. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic acid modulates the activity of PP2A through its metabolites, which can bind and alter PP2A-B72/B130 conformation, enhancing its phosphatase activity. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $88.00 $190.00 $500.00 $2400.00 $9200.00 $15000.00 | 2 | |
Sphingosine interacts with protein phosphatase 2A, and the PP2A-B72/B130 subunit may be affected by this interaction, potentially leading to enhanced dephosphorylation activities. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720, after phosphorylation in vivo, can modulate PP2A activity. It might interact with PP2A-B72/B130 regulatory subunits, augmenting PP2A's overall phosphatase activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
(R)-roscovitine is a cyclin-dependent kinase inhibitor that indirectly enhances PP2A-B72/B130 activity by altering the phosphorylation status of proteins that interact with PP2A, leading to a potential increase in PP2A holoenzyme formation. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $78.00 | ||
Lecithin has been reported to bind and activate PP2A. The interaction with the PP2A-B72/B130 regulatory subunit may lead to enhanced phosphatase activity. | ||||||