Polyoma virus large T antigen Activators
The Large T Antigen (LT) is a multifunctional protein encoded by the early region of the polyomavirus genome. It's critical for virus replication and transformation of host cells.The LT antigen is a DNA-binding protein involved in several cellular processes, including DNA replication, transcription regulation, and cell cycle progression. It binds to the origin of replication of the polyomavirus genome, initiates viral DNA replication, and modulates the expression of viral genes.The viral protein also interacts with several cellular proteins, notably with tumor suppressor proteins p53 and Retinoblastoma (Rb). By binding to these proteins, LT disrupts their function, leading to uncontrolled cell division, a hallmark of cancer. Therefore, LT antigen is considered an oncoprotein, contributing to the transformation of normal cells into cancerous cells.
Besides, the LT antigen has helicase activity, meaning it can unwind the double-stranded DNA, an important step in DNA replication. It also influences the host's immune response, helping the virus evade immune surveillance.The Large T Antigen is an essential tool for the polyomavirus but can have detrimental effects on host cells. Understanding its function and interaction with host proteins can provide valuable insights into the mechanisms of viral replication and transformation, potentially leading to the development of antiviral therapies.In summary, the Large T Antigen of polyomavirus is a multifunctional protein crucial for viral replication and cell transformation. It interacts with host cell proteins, disrupts cell cycle control, initiates viral DNA replication, and aids the virus in immune evasion.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, may indirectly influence LT by altering chromatin structure and affecting gene expression relevant to viral replication. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, another histone deacetylase inhibitor, could affect LT activity indirectly by modulating the expression of genes involved in cell cycle regulation and viral replication. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, may indirectly influence LT by altering the epigenetic landscape, potentially affecting viral integration and replication processes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, a histone deacetylase inhibitor, might impact LT activity by changing gene expression patterns in infected cells, influencing viral replication. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib, a CDK4/6 inhibitor, could indirectly affect LT by modulating cell cycle progression, potentially impacting the environment LT exploits for viral replication. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, involved in gene expression regulation, might influence LT indirectly by altering cellular pathways that the virus exploits for replication. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, may have an indirect effect on LT by influencing cellular growth pathways, potentially affecting the environment for viral replication. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin, an HSP90 inhibitor, might influence LT indirectly by affecting protein folding and stability, including proteins critical for viral replication. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide, a protein synthesis inhibitor, could indirectly affect LT by broadly inhibiting protein synthesis, impacting the cellular environment utilized by the virus. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132, a proteasome inhibitor, might impact LT activity by altering the degradation of cellular proteins important for viral replication. | ||||||