Polycystin-1L1 Activators
Polycystin-1L1 activators belong to a category of chemical agents that interact with a specific type of protein known as polycystin-1L1, which is encoded by the PKD1L1 gene. Polycystin-1L1 is part of the larger family of polycystin proteins that play significant roles in various cellular processes. These proteins are known for their involvement in the structure and function of cilia, which are hair-like projections found on the surface of many eukaryotic cells. The cilia are implicated in a multitude of cellular activities, including fluid flow, signal transduction, and the establishment of left-right asymmetry during embryonic development. Activators of polycystin-1L1 thus interact with the protein to modulate its function, potentially altering the behavior of the cilia and the cellular processes they influence. The exact mechanism by which these activators exert their effects on polycystin-1L1 can vary, but it typically involves binding to the protein and inducing a conformational change that increases its activity or the activity of associated signaling pathways.
The molecular intricacies of polycystin-1L1 activators are of considerable interest in the research of fundamental cellular functions and molecular biology. These activators can help in elucidating the complex pathways involving polycystin proteins and provide insights into the molecular mechanisms that govern cellular signaling and structure. Studying how polycystin-1L1 activators interact with their target protein helps in understanding the protein's normal physiological roles. Furthermore, such studies may reveal how mutations in the related genes might disrupt protein function and the consequences of these disruptions at the cellular level. The study of polycystin-1L1 and its activators is deeply rooted in biochemistry, cell biology, and genetics, informing broader scientific understanding of how cells maintain their structure, respond to external stimuli, and communicate with each other within the context of complex biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene that activates adenylyl cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate and thereby enhance the activity of Polycystin-1L1, as PKA-mediated phosphorylation can modulate the function of proteins involved in ciliary signaling and potentially Polycystin-1L1-associated pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin interacts with multiple components of cellular signaling pathways. By inhibiting NF-kB activation, it can shift the cellular signaling dynamics in a way that may enhance the activity of Polycystin-1L1 through relieving potential suppression of pathways associated with its function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which is involved in deacetylase activity that influences a variety of cellular pathways. Activation of SIRT1 by resveratrol could enhance the function of Polycystin-1L1 by modulating signaling pathways related to cellular stress and potentially affecting those associated with Polycystin-1L1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to inhibit GSK-3β, which is a critical regulator in the Wnt signaling pathway. By inhibiting GSK-3β, lithium potentially enhances the activity of Polycystin-1L1 through Wnt signaling pathway modulation, which is implicated in processes that could intersect with Polycystin-1L1 functions. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a β-adrenergic receptor agonist that increases cAMP levels, leading to PKA activation. This activation can enhance Polycystin-1L1 activity by modulating the same or overlapping signaling pathways influenced by increased cAMP and PKA activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to an increase in cAMP levels. The elevation of cAMP can indirectly activate signaling pathways involving PKA that could enhance the activity of Polycystin-1L1 by affecting related cellular functions. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its receptors, can activate PLC, leading to PKC activation. PKC activation can enhance the activity of Polycystin-1L1 by modulating calcium signaling and other pathways where PKC is a crucial mediator, potentially intersecting with Polycystin-1L1's activity. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol can activate estrogen receptors, leading to modulation of various signaling pathways. This modulation can enhance the activity of Polycystin-1L1 by affecting signaling pathways that regulate cell proliferation and differentiation, possibly intersecting with Polycystin-1L1's role. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates TRPV1, which is a calcium-permeable channel. Activation of TRPV1 by capsaicin can enhance Polycystin-1L1 activity by modulating calcium signaling patterns, which can intersect with the cellular functions mediated by Polycystin-1L1. | ||||||