Date published: 2026-4-11

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Pol III Inhibitors

Santa Cruz Biotechnology now offers a broad range of Pol III inhibitors for use in various applications. Pol III inhibitors are a crucial class of compounds in molecular biology and genetic research, primarily targeting RNA polymerase III (Pol III), an enzyme responsible for transcribing small RNA molecules, including tRNA and 5S rRNA. These inhibitors are invaluable tools for scientists studying the intricate mechanisms of gene expression regulation and RNA synthesis. By selectively inhibiting Pol III activity, researchers can dissect the specific roles of this enzyme in various cellular processes, such as growth, differentiation, and stress responses. The use of Pol III inhibitors has significantly advanced our understanding of transcriptional control and its implications in cell biology, providing insights into the broader landscape of genetic regulation. Furthermore, these inhibitors are instrumental in studying the interplay between Pol III and other transcriptional machinery components, shedding light on the complexities of cellular homeostasis and the potential for genetic modulation. Santa Cruz Biotechnology's extensive selection of Pol III inhibitors enables researchers to choose the most suitable compounds for their specific experimental needs, ensuring precision and reliability in their scientific inquiries. View detailed information on our available Pol III inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$269.00
$1050.00
26
(2)

α-Amanitin is a potent inhibitor of RNA polymerase II and III, specifically disrupting transcription processes in eukaryotic cells. Its unique cyclic peptide structure allows for strong binding to the enzyme's active site, preventing RNA synthesis. The compound's selective affinity for these polymerases leads to distinct kinetic profiles, significantly altering gene expression. Its stability in cellular environments enhances its effectiveness in modulating transcriptional activity, making it a critical tool in studying RNA dynamics.

Juglone

481-39-0sc-202675
sc-202675A
1 g
5 g
$67.00
$226.00
6
(1)

Juglone is a naturally occurring naphthoquinone that exhibits unique interactions with various biological systems. As a potent inhibitor of RNA polymerase III, it disrupts the transcription of small RNAs, influencing gene regulation. Its ability to form stable complexes with metal ions enhances its reactivity, while its redox properties facilitate electron transfer processes. Juglone's distinct molecular structure allows for selective binding, impacting cellular pathways and metabolic functions.