podoplanin Activators

Common podoplanin Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Dexamethasone CAS 50-02-2, PMA CAS 16561-29-8, PGE2 CAS 363-24-6 and Lysophosphatidic Acid CAS 325465-93-8.

Podoplanin activators are compounds that stimulate the activity or expression of podoplanin, a type-I transmembrane sialomucin-like glycoprotein. Widely expressed across various tissues, podoplanin has been identified in a number of cell types, including lymphatic endothelial cells, kidney podocytes, and certain types of cancer cells. The protein is characterized by its unique O-glycosylation pattern, which influences its interaction with other cellular and extracellular components.

One of the most recognized roles of podoplanin is its involvement in the development and maintenance of the lymphatic system. In lymphatic endothelial cells, podoplanin plays a crucial role in maintaining cell shape, promoting cell-cell interactions, and ensuring the proper formation of lymphatic vessels. The protein accomplishes these functions, in part, by binding to C-type lectin-like receptor 2 (CLEC-2) on platelets, an interaction that is essential for separating the lymphatic system from the blood vasculature during embryonic development. Beyond its roles in lymphangiogenesis, podoplanin has been implicated in various cellular processes, including cell migration, adhesion, and proliferation. Podoplanin activators, by enhancing the protein's activity or expression, can influence these cellular dynamics, impacting tissue development, regeneration, and homeostasis. Understanding the mechanisms and implications of podoplanin activation offers profound insights into the protein's multifaceted roles across different biological contexts. Exploring the realm of podoplanin activators emphasizes the significance of this glycoprotein in orchestrating intricate cellular behaviors, underlining its importance in tissue morphogenesis and maintenance.