PKN Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
K-252a is a potent modulator of pyruvate kinase M2 (PKM2), characterized by its ability to disrupt the enzyme's conformational dynamics. By selectively binding to specific allosteric sites, K-252a alters the dimer-tetramer transition, enhancing PKM2's catalytic efficiency. This compound's unique interaction profile promotes a more favorable substrate orientation, thereby accelerating reaction kinetics and influencing metabolic regulation in cellular environments. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A broad-spectrum kinase inhibitor that can inhibit PKN by competing with ATP binding, thus blocking its catalytic activity. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
A pan-PKC inhibitor that can reduce PKN phosphorylation and activation by inhibiting PKC, which is known to phosphorylate and activate PKN. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Another PKC inhibitor that can indirectly inhibit PKN by preventing PKC-mediated phosphorylation, which is essential for PKN activation. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
A natural inhibitor of PKC; by inhibiting PKC, sphingosine may reduce PKN activity given the dependence of PKN on PKC for activation. | ||||||
LY-333,531 Hydrochloride | 169939-93-9 | sc-364215 sc-364215A | 1 mg 5 mg | $94.00 $287.00 | 6 | |
A selective inhibitor of PKCβ isoforms, which could indirectly decrease PKN activation if PKN is downstream of PKCβ. | ||||||
Enzastaurin | 170364-57-5 | sc-364488 sc-364488A sc-364488B | 10 mg 50 mg 200 mg | $259.00 $612.00 $1721.00 | 3 | |
Originally developed as a PKCβ inhibitor, it could also reduce PKN activity through PKCβ-dependent pathways. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $84.00 $166.00 $302.00 $2091.00 $5212.00 $16657.00 | 51 | |
Often considered a PKCδ inhibitor, rottlerin can decrease PKN activity by inhibiting PKCδ or other kinases in PKN signaling pathways. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
A potent PKC inhibitor sensitive to light; can indirectly inhibit PKN by reducing PKC-mediated phosphorylation. | ||||||
GR24 | 76974-79-3 | sc-506577 | 250 µg | $241.00 | ||
An ATP-competitive inhibitor of PKC, which could also inhibit PKN activity by preventing PKC from phosphorylating and activating PKN. | ||||||