Pkc1 Activators
Pkc1 Activators consist of a collection of chemical compounds that serve to enhance the activity of Pkc1 by various mechanisms that are central to cellular signaling and functional regulation. The direct activators such as Phorbol 12-myristate 13-acetate (PMA) and Bryostatin 1 mimic the natural ligand diacylglycerol, binding to the regulatory domain of Pkc1 to initiate its kinase activity, which is essential for downstream signaling events that govern cellular processes like proliferation and apoptosis. Ingenol mebutate and Teleocidin also directly engage with the C1 domain of Pkc1, thereby facilitating its translocation and subsequent activation, which are critical for the regulation of cellular functions including growth and differentiation.
Moreover, other activators function by altering the intracellular environment to favor Pkc1 activation: Ionomycin, for instance, increases intracellular calcium levels, which is a crucial cofactor for Pkc1 activation. Similarly, Calcium Chloride serves to elevate these calcium levels, fulfilling the ion's role as a Pkc1 activator. The lipid-derived activators, such as Arachidonic, Linoleic, and Oleic acids, modulate the plasma membrane's lipid environment, which is a prerequisite for Pkc1's activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analogue that activates Pkc1 by mimicking diacylglycerol, the physiological activator of Pkc1. Binding of PMA to Pkc1 leads to its activation and subsequent phosphorylation of downstream substrates involved in various signaling pathways. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 is a naturally occurring compound that binds to the regulatory domain of Pkc1, leading to its activation and the enhancement of Pkc1's role in modulating cellular proliferation, differentiation, and apoptosis. | ||||||
Ingenol 3-angelate | 75567-37-2 | sc-364214 sc-364214A | 1 mg 5 mg | $189.00 $734.00 | 3 | |
Ingenol mebutate activates Pkc1 by binding to its diacylglycerol binding site, inducing Pkc1 translocation and activation, crucial for regulating cellular functions such as growth and survival. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analogue that can indirectly activate Pkc1 through the PKA pathway. PKA can phosphorylate inhibitors of Pkc1, leading to its disinhibition and activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, indirectly activating Pkc1, as calcium is an essential cofactor for Pkc1 activation. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid activates Pkc1 by altering the plasma membrane's lipid environment, enhancing Pkc1 membrane association and activity. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic acid modulates the membrane phospholipid milieu, which indirectly activates Pkc1 by promoting its translocation to the membrane and subsequent activation. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid affects the lipid composition of membranes, influencing Pkc1 activation by facilitating its interaction with the membrane. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
D-erythro-Sphingosine activates Pkc1 by binding to its regulatory domain, enhancing its activity in signal transduction related to cell proliferation and survival. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium chloride increases intracellular calcium levels, which is necessary for Pkc1 activation since Pkc1 is calcium-dependent. | ||||||