PKC Activators
Santa Cruz Biotechnology now offers a broad range of PKC Activators. Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKC Activators offered by Santa Cruz activate PKC and, in some cases, other cell growth and differentiation related proteins. View detailed PKC Activator specifications, including PKC Activator CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
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Items 1 to 10 of 40 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid (CAS 78111-17-8) is primarily known as a phosphatase inhibitor that targets PP1 and PP2A. While not a direct PKC activator, its inhibition of phosphatases can indirectly boost PKC activity. By suppressing phosphatase action, it prolongs the phosphorylated state of proteins, including PKC, enhancing its signaling pathways. This makes Okadaic Acid a useful tool for studying protein phosphorylation dynamics in cellular signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Mimics diacylglycerol (DAG) and binds to the C1 domain of PKCα, facilitating its translocation to the cell membrane where it becomes active. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Binds with high specificity to the C1 domain of PKCα, promoting its activation without causing down-regulation. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
1α,25-Dihydroxyvitamin D3 (CAS 32222-06-3), also known as calcitriol, is the active form of vitamin D3. It is known to have a role in calcium homeostasis, but it also acts as an activator of Protein Kinase C (PKC). It achieves PKC activation indirectly by binding to its nuclear vitamin D receptor (VDR). This receptor-ligand complex then interacts with other cellular components, leading to an increase in intracellular calcium levels, which in turn activates calcium-dependent PKC isoforms. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $138.00 $530.00 | 24 | |
Binds to the C1 domain, similar to phorbol esters, activating PKCα without promoting tumor formation. | ||||||
1,2-Dioleoyl-sn-glycerol | 24529-88-2 | sc-204958 sc-204958A | 10 mg 25 mg | $114.00 $170.00 | ||
Another DAG analog that binds to the C1 domain, thereby activating PKCα. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
Synthetic analog of DAG that competes for the same binding site on the C1 domain of PKCα, leading to its activation. | ||||||
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $117.00 $444.00 | 1 | |
1-Oleoyl-2-acetyl-sn-glycerol (OAG) with CAS 86390-77-4 is a synthetic analog of diacylglycerol (DAG), which is a physiological activator of Protein Kinase C (PKC). OAG acts by binding to the C1 domain of PKC, mimicking the action of endogenous DAG. This binding leads to the translocation and activation of PKC at the cellular membrane, allowing it to participate in various signaling pathways. | ||||||
α-Amyloid Precursor Protein Modulator | 497259-23-1 | sc-204424 | 1 mg | $322.00 | 2 | |
α-Amyloid Precursor Protein Modulator (CAS 497259-23-1) is a chemical compound known for its ability to modulate the metabolism of the amyloid precursor protein (APP). It indirectly activates Protein Kinase C (PKC) by affecting cellular pathways that ultimately lead to PKC activation. This activation of PKC can then influence APP processing, steering it away from amyloidogenic pathways. The compound plays a role in intracellular signaling and is often used in research settings. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic Acid (CAS 112-80-1) is a monounsaturated fatty acid that can act as an indirect activator of Protein Kinase C (PKC). It achieves this by being metabolized into diacylglycerol (DAG), an endogenous activator of PKC. Once converted to DAG, it can bind to the C1 domain of PKC, facilitating the enzyme's translocation to the cell membrane and its subsequent activation, thereby participating in various cellular signaling pathways. | ||||||