PHC2 Activators

Polyhomeotic-like protein 2 (PHC2) is a part of the Polycomb group (PcG) proteins, which are essential for the regulation of developmental genes through chromatin remodeling and transcriptional repression. PHC2 is a component of the Polycomb repressive complex 1 (PRC1), which is known for its role in maintaining the transcriptional silencing of genes over successive cell generations, a process known as cellular memory.The PRC1 complex, including PHC2, contributes to the post-translational modification of histones, particularly the monoubiquitination of histone H2A. This modification is a hallmark of PcG-mediated gene repression and is crucial for the stable inheritance of repressed states of gene expression during cell division.

PHC2 is involved in various developmental processes, and its dysregulation can lead to developmental abnormalities and has been associated with cancer. The protein interacts with other PRC1 components to orchestrate the repression of target genes, influencing cell fate decisions, differentiation, and proliferation.Research on PHC2 has provided insights into the molecular mechanisms of epigenetic regulation. It has also underscored the importance of precise control of gene expression during development and the maintenance of stem cell pluripotency.