Date published: 2026-4-10

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PGC-1 Activators

Santa Cruz Biotechnology now offers a broad range of PGC-1 Activators for use in various applications. PGC-1 Activators are essential tools in the study of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), a transcriptional coactivator that plays a critical role in regulating cellular energy metabolism, mitochondrial biogenesis, and oxidative stress responses. By activating PGC-1α, these compounds enhance the expression of genes involved in mitochondrial function, fatty acid oxidation, and glucose metabolism. This makes PGC-1 Activators invaluable for investigating the mechanisms of energy homeostasis and metabolic adaptation in various cell types and tissues. In scientific research, PGC-1 Activators are used to explore how PGC-1α modulates metabolic pathways under different physiological conditions, such as exercise, fasting, and temperature changes. Researchers employ these activators to study the impact of enhanced PGC-1α activity on mitochondrial dynamics, including mitochondrial fusion, fission, and turnover. These studies provide insights into how cells maintain energy balance and respond to metabolic stress. Additionally, PGC-1 Activators are utilized to investigate the role of PGC-1α in muscle fiber type switching, adipocyte differentiation, and thermogenesis, offering a deeper understanding of tissue-specific metabolic regulation. By using PGC-1 Activators, scientists can develop experimental models to study the complex interactions between metabolic pathways and their regulatory networks, advancing our knowledge of cellular energy metabolism and its implications for health and disease. View detailed information on our available PGC-1 Activators by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

U-0126 acts as a potent modulator of PGC-1, engaging in specific interactions that enhance mitochondrial biogenesis. Its unique structure allows for selective binding to regulatory domains, influencing transcriptional activity. The compound's ability to stabilize protein conformations leads to altered gene expression patterns, impacting energy metabolism and oxidative stress responses. This dynamic interplay underscores its significance in cellular energy regulation and metabolic adaptation.

2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide

924416-43-3sc-396658
sc-396658A
10 mg
50 mg
$112.00
$454.00
1
(0)

2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide exhibits a distinctive mechanism of action as a PGC-1 modulator, characterized by its ability to disrupt protein-protein interactions within metabolic pathways. This compound facilitates the recruitment of coactivators, enhancing the transcriptional response to energy demands. Its unique molecular architecture promotes specific conformational changes in target proteins, thereby influencing metabolic flux and cellular homeostasis.