Pellino 1 Activators
Pellino 1 is a crucial regulatory protein involved in the activation of innate immune responses and inflammatory signaling pathways. Functionally, Pellino 1 serves as an E3 ubiquitin ligase, responsible for catalyzing the ubiquitination of target proteins within the context of various cellular signaling cascades. Specifically, Pellino 1 plays a pivotal role in the activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways in response to diverse extracellular stimuli, including pathogen-associated molecular patterns (PAMPs) and pro-inflammatory cytokines. Through its interactions with components of Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling complexes, Pellino 1 facilitates the ubiquitination and subsequent activation of downstream signaling molecules, ultimately leading to the induction of pro-inflammatory gene expression and the initiation of innate immune responses.
Activation of Pellino 1 involves complex regulatory mechanisms aimed at initiating and propagating inflammatory signaling cascades in response to external stimuli. Upon recognition of PAMPs or cytokines by TLRs or IL-1Rs, Pellino 1 is recruited to the signaling complexes through protein-protein interactions, leading to its activation. Phosphorylation events mediated by upstream kinases, such as IRAKs and TAK1, further stimulate Pellino 1 activity, promoting its ubiquitin ligase function and facilitating the ubiquitination of target proteins. Additionally, post-translational modifications and scaffold proteins may regulate Pellino 1 activation, fine-tuning its activity and integrating diverse signaling inputs to orchestrate robust immune responses. Understanding the intricate mechanisms underlying Pellino 1 activation provides insights into the regulation of inflammatory signaling pathways and offers targets for intervention in inflammatory diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187, a calcium ionophore, directly activates Pellino 1 by inducing calcium influx. The increased intracellular calcium levels lead to the activation of calmodulin-dependent signaling, which in turn directly stimulates Pellino 1. A23187 provides a specific mechanism for the direct activation of Pellino 1 through the modulation of calcium-dependent cellular pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, an adenylate cyclase activator, activates Pellino 1 by increasing intracellular cAMP levels. Elevated cAMP activates protein kinase A (PKA), leading to downstream signaling that directly stimulates Pellino 1. Forskolin provides a specific mechanism for the direct activation of Pellino 1 through the modulation of cAMP-dependent pathways, highlighting the role of second messenger systems in Pellino 1 activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA, a protein kinase C (PKC) activator, directly activates Pellino 1 by inducing PKC-dependent phosphorylation. The activation of PKC by PMA leads to the direct stimulation of Pellino 1 through phosphorylation events. PMA provides a specific mechanism for the direct activation of Pellino 1 through the modulation of PKC-dependent signaling pathways, emphasizing the regulatory role of PKC in Pellino 1 activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin, a SERCA pump inhibitor, indirectly activates Pellino 1 by inducing calcium release from the endoplasmic reticulum. The depletion of ER calcium activates calcium-sensitive pathways, leading to the indirect stimulation of Pellino 1. Thapsigargin provides a specific mechanism for the indirect activation of Pellino 1 through the modulation of calcium-dependent cellular pathways, highlighting the interplay between intracellular calcium dynamics and Pellino 1 activation. | ||||||
8-CPT-cAMP | 93882-12-3 | sc-201569 sc-201569A | 20 mg 100 mg | $85.00 $310.00 | 19 | |
8-CPT-cAMP, a cell-permeable cAMP analog, directly activates Pellino 1 by mimicking the effects of Forskolin. By increasing intracellular cAMP levels, 8-CPT-cAMP activates PKA, leading to direct stimulation of Pellino 1. This compound provides an alternative mechanism for the direct activation of Pellino 1 through the modulation of cAMP-dependent pathways, further underscoring the importance of second messenger systems in Pellino 1 activation. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid, a natural pentacyclic triterpenoid, directly activates Pellino 1 by enhancing the activity of protein phosphatase 2A (PP2A). The activation of PP2A by Betulinic Acid results in the dephosphorylation of Pellino 1, leading to its direct stimulation. Betulinic Acid provides a specific mechanism for the direct activation of Pellino 1 through the modulation of PP2A-dependent pathways, emphasizing the regulatory role of protein phosphatases in Pellino 1 activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A, a potent protein phosphatase inhibitor, indirectly activates Pellino 1 by preventing the dephosphorylation of critical residues. The inhibition of protein phosphatases, especially PP2A, leads to the sustained phosphorylation and activation of Pellino 1. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
GSK-3 Inhibitor IXindirectly activates Pellino 1 by preventing GSK-3-mediated phosphorylation. The inhibition of GSK-3 results in the stabilization and activation of Pellino 1 through decreased degradation. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $46.00 $249.00 | 2 | |
1,2-Dioctanoyl-sn-glycerol, a second messenger, directly activates Pellino 1 by activating PKC. DAG induces the translocation of PKC to the cell membrane, leading to the direct phosphorylation and activation of Pellino 1. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K 8644, an L-type calcium channel activator, directly activates Pellino 1 by inducing calcium influx through L-type calcium channels. The increased intracellular calcium levels lead to the direct activation of Pellino 1. Bay K 8644 provides a specific mechanism for the direct activation of Pellino 1 through the modulation of calcium-dependent cellular pathways, emphasizing the regulatory role of calcium channels in Pellino 1 activation. | ||||||