PEG Linkers

Endo-BCN-PEG2-PFP ester is a specialized PEG linker characterized by its unique endo-bicyclo[6.1.0]nonyne structure, which enables rapid and selective cycloaddition reactions. The presence of the PFP ester group enhances reactivity, facilitating efficient conjugation with various nucleophiles. Its compact design allows for improved spatial orientation in molecular assemblies, promoting effective interactions while maintaining low steric hindrance, thus optimizing reaction kinetics in diverse applications.

Endo-BCN-PEG4-PFP ester is a versatile PEG linker distinguished by its endo-bicyclo[6.1.0]nonyne framework, which supports efficient strain-promoted azide-alkyne cycloaddition. The PFP ester moiety enhances electrophilicity, allowing for swift reactions with nucleophiles. Its extended PEG chain improves solubility and biocompatibility, while the linker’s flexibility aids in conformational adaptability, ensuring optimal molecular interactions in various environments.

Endo-BCN-PEG4-t-butyl ester is a unique PEG linker characterized by its endo-bicyclo[6.1.0]nonyne structure, which facilitates rapid and selective reactions through strain-promoted cycloaddition. The t-butyl ester group enhances hydrophobic interactions, promoting stability in diverse environments. Its PEG segment contributes to increased solubility and reduced aggregation, while the linker’s inherent flexibility allows for dynamic conformational changes, optimizing interactions with various substrates.

Endo-BCN-PEG6-t-butyl ester features a distinctive endo-bicyclo[6.1.0]nonyne framework that enables efficient strain-promoted azide-alkyne cycloaddition, enhancing reaction kinetics. The extended PEG chain improves solubility and biocompatibility, while the t-butyl ester moiety introduces steric bulk, influencing molecular interactions. This compound's structural flexibility allows for tailored conformational adjustments, facilitating optimal binding and interaction with target molecules in diverse chemical environments.

m-PEG4-amine serves as a versatile PEG linker, characterized by its amine functionality that promotes strong hydrogen bonding and enhances solubility in aqueous environments. Its four ethylene glycol units provide a balance of hydrophilicity and flexibility, allowing for effective molecular spacing and reduced steric hindrance. This compound's unique structure facilitates rapid conjugation reactions, enabling efficient formation of stable linkages in various chemical contexts.

Endo-BCN-PEG2-alcohol is a specialized PEG linker featuring a unique bicyclic structure that enhances its reactivity through strain relief during cycloaddition reactions. Its two ethylene glycol units contribute to a hydrophilic character, promoting solubility and biocompatibility. The alcohol moiety allows for versatile functionalization, enabling selective interactions and facilitating efficient coupling with various biomolecules, while maintaining a low steric profile for improved accessibility in conjugation processes.

Biotin-PEG3-Mal is a versatile PEG linker characterized by its maleimide functional group, which enables specific thiol-reactive conjugation. The three ethylene glycol units enhance solubility and flexibility, allowing for efficient molecular interactions in diverse environments. Its biotin component facilitates strong binding to avidin or streptavidin, promoting targeted assembly in complex systems. This linker’s unique properties support precise modifications and enhance the stability of conjugated structures.

Exo-BCN-PEG4-PFP ester is a specialized PEG linker featuring a cyclooctyne moiety that enables rapid and selective strain-promoted alkyne-azide cycloaddition reactions. The four ethylene glycol units provide exceptional solubility and biocompatibility, facilitating smooth integration into various chemical environments. Its PFP ester functionality allows for efficient activation and subsequent conjugation, promoting robust molecular interactions and enhancing the stability of linked constructs.

Biotin-PEG6-Mal is a versatile PEG linker characterized by its maleimide group, which enables specific and efficient thiol-maleimide conjugation. The six ethylene glycol units enhance solubility and flexibility, allowing for optimal spatial arrangement in complex biological systems. This linker exhibits excellent stability under physiological conditions, promoting reliable and reproducible coupling reactions. Its biotin component facilitates strong interactions with avidin or streptavidin, enhancing the specificity of molecular assemblies.

Biotin-PEG11-Mal is a specialized PEG linker featuring an extended chain of eleven ethylene glycol units, which significantly improves solubility and biocompatibility. The maleimide moiety allows for selective conjugation with thiol groups, ensuring precise targeting in various applications. Its unique structure promotes enhanced molecular mobility and stability, facilitating efficient reaction kinetics. The biotin segment provides robust binding capabilities, enabling effective integration into complex biomolecular networks.