PEA-15 Activators
PEA-15 activators encompass a group of compounds that may enhance the function of PEA-15 through indirect means, primarily by influencing signaling pathways that regulate its phosphorylation status and its interactions with other proteins. Compounds like forskolin and dibutyryl cAMP can increase cellular cAMP levels, which may lead to changes in the phosphorylation of PEA-15, thereby influencing its ability to bind to partners such as ERK1/2.
Phosphatase inhibitors like okadaic acid and calyculin A may increase the phosphorylated state of proteins, including PEA-15, potentially enhancing its activity. Kinase inhibitors, while primarily used to inhibit specific kinases, can have indirect effects on signaling pathways that involve PEA-15. For instance, PD98059, an MEK inhibitor, could lead to changes in ERK1/2 activity, thereby affecting PEA-15's interaction with ERK1/2. Similarly, inhibitors of JNK, PI3K, p38 MAPK, and mTOR could alter cellular signaling in a way that indirectly modulates the function of PEA-15.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, potentially affecting PEA-15 phosphorylation and its interaction with ERK1/2. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
cAMP analog that can mimic cAMP's effect on cellular pathways, possibly leading to changes in PEA-15 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC), which could lead to phosphorylation of PEA-15 and affect its protein interactions. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Protein phosphatase inhibitor that may increase the phosphorylated state of proteins like PEA-15. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Another phosphatase inhibitor that could potentially increase PEA-15 phosphorylation and its activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor that might indirectly affect PEA-15 by altering ERK1/2 signaling pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that could influence PEA-15's function by modifying stress-related signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that might indirectly modulate PEA-15's role in insulin signaling and glucose metabolism. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Cyclin-dependent kinase inhibitor that may influence the cell cycle and potentially PEA-15's interactions with other proteins. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that can affect protein synthesis and indirectly influence PEA-15 function. | ||||||