PDSS1 Activators
PDSS1 Activators are a unique class of chemical compounds that specifically enhance the functional activity of PDSS1, an enzyme responsible for the first step in coenzyme Q (CoQ) biosynthesis. These activators generally enhance PDSS1 activity by increasing the availability of substrates and cofactors, or by promoting a favourable environment for the enzyme to function. Compounds like Acetyl-CoA and Malonyl-CoA directly enhance PDSS1 activity by serving as substrates for the enzyme. A higher concentration of these substrates allows for more CoQ synthesis, directly enhancing PDSS1 activity.
On the other hand, Manganese, FAD, and Magnesium act as cofactors for PDSS1, with their increased availability facilitating the binding of substrates and the catalytic reaction, thereby enhancing PDSS1 activity. NADH, an important reducing agent, indirectly enhances PDSS1 activity by maintaining a reducing environment essential for the enzyme's function. Pyruvate, Oxaloacetate, Citrate, and Succinate are intermediates in cellular metabolism that can be converted into substrates for PDSS1 or facilitate conditions favourable for PDSS1 activity, thus indirectly enhancing its function. Coenzyme Q10, a product of the reaction catalysed by PDSS1, can enhance the feedback activation of PDSS1, indirectly enhancing its activity. Finally, Isopentenyl pyrophosphate (IPP), a substrate for the downstream enzymes in the CoQ biosynthesis pathway, canindirectly enhance the functional activity of PDSS1 by driving the flux through the CoQ biosynthesis pathway.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $46.00 $80.00 $5712.00 | 3 | |
Acetyl-CoA is a substrate for PDSS1, the enzyme responsible for the first step in coenzyme Q (CoQ) biosynthesis. A higher concentration of Acetyl-CoA can directly enhance the functional activity of PDSS1 by providing more substrate for CoQ synthesis. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Malonyl-CoA is a substrate for PDSS1. Increased levels of Malonyl-CoA can enhance PDSS1 activity by providing more substrate for CoQ synthesis. | ||||||
Manganese | 7439-96-5 | sc-250292 | 100 g | $270.00 | ||
Manganese is a cofactor for many enzymes including PDSS1. Increased availability of manganese can enhance the functional activity of PDSS1 by facilitating the binding of substrates and the catalytic reaction. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NADH is an important reducing agent in cellular metabolism. The PDSS1 enzyme requires a reducing environment for its activity. Therefore, high levels of NADH can indirectly enhance the functional activity of PDSS1 by maintaining a reducing environment. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $40.00 $94.00 | ||
Pyruvate is a key intermediate in cellular metabolism and its conversion to acetyl-CoA provides substrate for PDSS1. Hence, an increase in pyruvate can indirectly enhance the functional activity of PDSS1. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is a product of the reaction catalysed by PDSS1. Increased availability of Coenzyme Q10 can enhance the feedback activation of PDSS1, indirectly enhancing its activity. | ||||||
Oxaloacetic Acid | 328-42-7 | sc-279934 sc-279934A sc-279934B | 25 g 100 g 1 kg | $300.00 $944.00 $7824.00 | 1 | |
Oxaloacetate is an intermediate in cellular metabolism that can be converted into malonyl-CoA, a substrate for PDSS1. Increased levels of oxaloacetate can indirectly enhance the functional activity of PDSS1 by providing more substrate for CoQ synthesis. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $49.00 $108.00 $142.00 $243.00 $586.00 | 1 | |
Citrate is an intermediate in cellular metabolism that can be converted into acetyl-CoA and oxaloacetate, substrates for PDSS1. Increased levels of citrate can indirectly enhance PDSS1 activity by providing more substrate for CoQ synthesis. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $44.00 $74.00 $130.00 | ||
Succinate is an intermediate in cellular metabolism that can be used to generate FADH2, which maintains a reducing environment beneficial for PDSS1 activity. Increased levels of succinate can indirectly enhance PDSS1 activity. | ||||||