PCP4L1 Inhibitors
PCP4L1 inhibitors are a class of chemical compounds that target and inhibit PCP4L1, a protein closely related to Purkinje cell protein 4 (PCP4), which is known to be involved in calcium signaling and the regulation of calmodulin. PCP4L1, like PCP4, binds to calmodulin, a calcium-binding messenger protein that plays a crucial role in translating calcium signals into cellular responses. By interacting with calmodulin, PCP4L1 influences calcium-dependent processes such as muscle contraction, cell motility, and neurotransmitter release. Inhibition of PCP4L1 disrupts its interaction with calmodulin, potentially altering calcium signaling pathways and affecting various cellular functions dependent on precise calcium regulation.
The action of PCP4L1 inhibitors involves binding to the PCP4L1 protein or its interface with calmodulin, preventing the protein from modulating calcium signaling pathways. This inhibition can lead to changes in calcium dynamics within the cell, affecting processes such as muscle coordination, synaptic activity, and intracellular signaling. PCP4L1 inhibitors serve as important tools for researchers studying the role of calcium signaling in various physiological functions. By blocking PCP4L1 activity, scientists can explore how this protein contributes to the fine-tuning of calcium-dependent cellular processes and gain a better understanding of its role in maintaining calcium homeostasis. The inhibition of PCP4L1 also provides insights into the broader mechanisms of calcium-mediated signal transduction, highlighting the importance of protein-calmodulin interactions in cellular regulation and the coordination of complex biological pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels within cells. Elevated cAMP activates PKA, which can phosphorylate various substrates. As a result, PKA activation could enhance PCP4L1 activity by phosphorylating it or associated regulatory proteins, thereby influencing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. By elevating calcium levels, ionomycin could activate calcium-dependent protein kinases which may then phosphorylate PCP4L1, enhancing its activity or interaction with other cellular components. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC, when activated, can phosphorylate a wide range of substrates, including proteins that could interact with or modify PCP4L1, potentially enhancing its activity through post-translational modifications. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a polyphenol compound from green tea, can inhibit several protein kinases. By inhibiting competitive signaling pathways, EGCG could indirectly enhance signaling pathways that upregulate PCP4L1 activity, through a shift in the signaling balance within the cell. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has multiple cellular targets and can inhibit various kinases. It may enhance PCP4L1 activity by modulating signaling pathways that converge on or regulate PCP4L1 function, such as inhibiting competitive pathways or influencing cellular localization of the protein. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can modulate the PI3K/Akt pathway. While typically an inhibitor, it may enhance PCP4L1 activity by reducing negative feedback loops within the PI3K/Akt pathway, potentially allowing PCP4L1 to be more active as part of a compensatory cellular response. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor, leading to increased cAMP levels within the cell. Higher cAMP may activate PKA, which could phosphorylate PCP4L1 or related proteins and enhance PCP4L1 signaling or stability. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
db-cAMP is a cAMP analog that can permeate cell membranes and directly activate cAMP-dependent pathways. Its role in PKA activation could lead to phosphorylation events that enhance PCP4L1 function. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast inhibits phosphodiesterases, particularly PDE5, leading to increased cAMP and cGMP levels. The elevation of these cyclic nucleotides could enhance PKA and PKG activity, respectively, which may then enhance PCP4L1 activity directly or via interaction with secondary proteins. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator that can induce stress-activated protein kinase pathways. By activating JNK, anisomycin could lead to phosphorylation cascades that enhance PCP4L1 activity or its integration into signaling complexes. | ||||||