PCMT1 Inhibitors
Given the function of PCMT1 in the repair of damaged aspartyl residues in proteins, the class of PCMT1 inhibitors would include compounds that can either compete with the enzyme's natural substrate or affect the availability of the methyl donor, S-adenosylmethionine (SAM). PCMT1 relies on SAM to donate a methyl group to the damaged residues, a critical step in the repair process. Therefore, any compound that can deplete SAM or inhibit its regeneration could indirectly inhibit PCMT1 activity.
The inhibition of PCMT1 could also be achieved by targeting the enzyme's catalytic site, where the isoaspartyl residue is recognized and repaired. However, this strategy is theoretical, as no known chemicals are designed explicitly for this purpose. Instead, the indirect approach of altering SAM levels or availability remains a plausible route for influencing PCMT1 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sinefungin | 58944-73-3 | sc-203263 sc-203263B sc-203263C sc-203263A | 1 mg 100 mg 1 g 10 mg | $271.00 $5202.00 $40368.00 $704.00 | 4 | |
A natural product inhibitor of SAM-dependent methyltransferases, could potentially inhibit PCMT1 by competing with SAM. | ||||||
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $122.00 | 1 | |
A byproduct of polyamine biosynthesis that inhibits SAM-dependent methyltransferases, potentially affecting PCMT1. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A cytidine analog that incorporates into DNA and traps DNA methyltransferases, could indirectly affect methylation cycles and PCMT1. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
Known to inhibit DNA methyltransferase and could affect global methylation levels, potentially influencing PCMT1. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor, could indirectly influence methylation processes related to PCMT1. | ||||||
Procaine | 59-46-1 | sc-296134 sc-296134A sc-296134B sc-296134C | 25 g 50 g 500 g 1 kg | $110.00 $193.00 $407.00 $628.00 | 1 | |
A DNA methylation inhibitor, which could potentially affect methylation donors and indirectly PCMT1 function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A nucleoside analog of cytidine that can be incorporated into RNA and DNA and inhibit methylation, potentially affecting PCMT1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A catechin found in green tea with a broad range of biological effects, including potential inhibition of methyltransferases, possibly affecting PCMT1. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Aldehyde dehydrogenase inhibitor that can chelate metals and has been shown to affect various methyltransferases, possibly including PCMT1. | ||||||