PCDH8 Activators
PCDH8 Activators arechemical compounds that modulate the activity of the PCDH8 gene. PCDH8, or Protocadherin 8, is a member of the cadherin superfamily, which encodes calcium-dependent cell adhesion proteins. These proteins play crucial roles in various cellular processes, including cell-cell recognition, adhesion, and communication. PCDH8, specifically, is involved in the development and maintenance of neural circuits in the central nervous system. The activators associated with PCDH8 are believed to influence the expression or function of this gene, thereby impacting cellular interactions and signaling pathways.
Researchers are keenly interested in understanding the mechanisms by which PCDH8 Activators exert their effects on cellular processes. These compounds may act through various molecular pathways, including those involved in intracellular signaling cascades and gene expression regulation. By selectively modulating PCDH8, these activators have the potential to fine-tune the intricate network of cellular communication, particularly in the context of neural development. The exploration of PCDH8 Activators opens up avenues for investigating the intricate molecular landscape underlying cell adhesion and neural connectivity, shedding light on the fundamental biology of cellular interactions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels, which in turn activates PKA. PKA phosphorylation can influence cell adhesion processes in neurons, potentially enhancing the adhesion function of PCDH8. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, which prevents cAMP breakdown, indirectly promoting PKA activity. This increased PKA activity could enhance the PCDH8 function in synaptic plasticity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can increase cAMP levels and thereby activate PKA. Enhanced PKA activity may influence PCDH8's role in neuronal growth and guidance. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits multiple kinases, altering signaling pathways involved in cell adhesion and migration. This could affect cellular processes where PCDH8 is a key component, such as neuron-neuron interactions. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA. It can enhance the phosphorylation of proteins involved in cell adhesion, potentially affecting PCDH8's function in synaptic plasticity. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine induces autophagy which can affect synaptic plasticity. Autophagy has been implicated in the regulation of synaptic components, potentially enhancing the functional activity of PCDH8 in synaptic maintenance. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression and neuronal differentiation. It could influence the pathways that modulate synaptic plasticity, indirectly leading to enhanced PCDH8 function in neuronal connections. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, a kinase involved in many signaling pathways including Wnt signaling. Inhibition of GSK-3β can lead to enhanced synaptic plasticity where PCDH8 may play a role. | ||||||