PC-PLD1B Inhibitors
PC-PLD1B inhibitors are a class of chemical compounds that specifically target phosphatidylcholine-specific phospholipase D1B (PC-PLD1B), an enzyme involved in the metabolism of phospholipids within cellular membranes. PC-PLD1B catalyzes the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline, a reaction that plays a pivotal role in intracellular signaling and membrane dynamics. By modulating the activity of PC-PLD1B, these inhibitors help researchers explore the enzyme's role in various cellular processes such as vesicle trafficking, cytoskeletal rearrangement, and signal transduction pathways.
The design and synthesis of PC-PLD1B inhibitors involve advanced techniques like structure-based drug design and molecular docking studies to identify molecules that can effectively bind to the enzyme's active site. These inhibitors may include small organic compounds, peptides, or other biologically active molecules engineered to interact specifically with PC-PLD1B. High-throughput screening methods are often employed to evaluate the efficacy and specificity of potential inhibitors. By utilizing these compounds in laboratory settings, scientists can gain deeper insights into the functional mechanisms of PC-PLD1B and its impact on cellular physiology, contributing to a better understanding of lipid-mediated signaling pathways and membrane-associated processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil, as a nucleotide analog, could disrupt the synthesis of mRNA for PC-PLD1B, leading to a reduction in the production of the enzyme from the transcriptional stage. | ||||||
D609 | 83373-60-8 | sc-201403 sc-201403A | 5 mg 25 mg | $185.00 $564.00 | 7 | |
D609's inhibition of phosphatidylcholine-specific phospholipase C may lead to a reduced production of diacylglycerol, which could decrease the stimulus for PC-PLD1B expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin could downregulate the expression of PC-PLD1B by inhibiting upstream kinase signals, which may lead to reduced activation of transcription factors responsible for the enzyme's expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may decrease the transcriptional activity of genes encoding PC-PLD1B by inhibiting nuclear factor-kappa B (NF-κB), a transcription factor that can enhance gene expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could inhibit the expression of PC-PLD1B by activating sirtuins, which may lead to the deacetylation of histones and a more condensed chromatin structure, reducing transcriptional activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126, by inhibiting mitogen-activated protein kinase (MAPK), could lead to reduced phosphorylation of transcription factors that are crucial for PC-PLD1B expression, thus decreasing its expression levels. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein could downregulate PC-PLD1B expression by inhibiting tyrosine kinases that are part of the signaling cascade responsible for the enzyme's expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 may reduce PC-PLD1B expression by inhibiting phosphoinositide 3-kinases (PI3K), which are involved in the signaling pathways that control the transcription of the PC-PLD1B gene. | ||||||