PARP-7 Activators
PARP-7 Activators are a collection of chemical compounds that indirectly or directly enhance the enzymatic function of PARP-7. Resveratrol is one such activator that by stimulating SIRT1, leads to the deacetylation and consequent activation of PARP-7's ADP-ribosyltransferase activity. Similarly, compounds that increase the levels of NAD+, such as Nicotinamide adenine dinucleotide itself and its precursors Nicotinamide mononucleotide and β-Nicotinamide mononucleotide, bolster PARP-7's activity by providing more substrate for its enzymatic reactions. Spermidine's role in autophagy, through EP300 inhibition, also indirectly supports the upregulation of PARP-7, reinforcing its role in DNA repair and cellular stress responses. Furthermore, Quercetin's inhibition of SIRT1 can result in an increase of acetylated PARP-7, thereby enhancing its activity, while paradoxical effects are observed with PARP inhibitors like PJ-34, which may initially cause a compensatory increase in PARP-7 activity.
Additionally, 6(5H)-Phenanthridinone, while a competitive inhibitor of PARP, can create a reactive upsurge in PARP-7 activity due to a cellular feedback mechanism. Tiq-A's inhibitory action on PARP-1 and PARP-2 may lead to a compensatory cellular response that indirectly upregulates PARP-7 activity. This array of chemical interactions illustrates the complex regulatory environment surrounding PARP-7 activity. The intricate balance of activation and inhibition across different pathways underscores the sophisticated modulation of PARP-7's role in maintaining genomic stability and cellular homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound, is known to activate SIRT1, which in turn can deacetylate PARP-7, enhancing its ADP-ribosyltransferase activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
Nicotinamide adenine dinucleotide (NAD+) is a substrate for PARP-7, and increased levels of NAD+ can directly enhance PARP-7's enzymatic activity. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
Nicotinamide mononucleotide (NMN) is a precursor of NAD+ and can indirectly increase PARP-7 activity by raising intracellular NAD+ levels. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine has been shown to induce autophagy through inhibition of the acetyltransferase EP300, which can lead to the upregulation of PARP-7 activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, can inhibit SIRT1, leading to increased acetylation and activation of PARP-7 as SIRT1 negatively regulates PARP-7 through deacetylation. | ||||||
PARP Inhibitor VIII, PJ34 | 344458-15-7 | sc-204161 sc-204161A | 1 mg 5 mg | $58.00 $142.00 | 20 | |
PJ-34 is a potent PARP inhibitor, but paradoxically, low doses have been reported to transiently enhance PARP-7 activity before inhibition takes effect. | ||||||
6(5H)-Phenanthridinone | 1015-89-0 | sc-200124 | 200 mg | $20.00 | 5 | |
6(5H)-Phenanthridinone is known to inhibit PARP enzymes competitively, but may also cause a feedback loop that enhances PARP-7 activity as a response. | ||||||