Paralemmin 2 Activators
Paralemmin 2 activators play a pivotal role in the regulation of this protein's association with the plasma membrane and its involvement in membrane dynamics. These activators typically function through the modulation of intracellular cAMP levels and the activation of protein kinase A (PKA). For example, certain compounds that act as beta-adrenergic agonists or adenylyl cyclase activators initiate a signaling cascade that culminates in the production of cAMP, subsequently activating PKA. Once PKA is active, it targets Paralemmin 2 for phosphorylation, which has been shown to influence the protein's membrane dynamics and protein-protein interactions. Additionally, resistance to cAMP degradation is another mechanism through which these activators operate. By inhibiting phosphodiesterases, the degradation of cAMP is prevented, resulting in sustained PKA activity and thereby maintaining Paralemmin 2 in a phosphorylated state, which is crucial for its active involvement in membrane trafficking and cellular signaling pathways.
Furthermore, Paralemmin 2 activation can be influenced by the modulation of PKC pathways, as certain activators that target PKC could lead to the phosphorylation of Paralemmin 2, thus affecting its localization and function within the cell. Other signaling molecules that activate G-protein-coupled receptors contribute to the rise in intracellular cAMP levels, further potentiating PKA-mediated phosphorylation of Paralemmin 2. This phosphorylation may control Paralemmin 2's role in organizing lipid rafts and influencing synaptic plasticity, which is vital for the modulation of neuronal connectivity and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator increasing cAMP levels. Elevated cAMP enhances Paralemmin 2 activity by protein kinase A (PKA) dependent phosphorylation, which can lead to membrane association changes. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Beta-adrenergic agonist that leads to cAMP production. cAMP accumulation activates PKA, which then can phosphorylate Paralemmin 2, enhancing its membrane dynamics and protein-protein interactions. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Phosphodiesterase inhibitor which prevents cAMP degradation, thus indirectly increasing PKA activity and potentially enhancing Paralemmin 2 phosphorylation and activity related to membrane trafficking. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activator of protein kinase C (PKC) which could phosphorylate Paralemmin 2, affecting its association with the plasma membrane and possibly its role in membrane curvature and dynamics. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
cAMP analog resistant to degradation, activating PKA and potentially leading to enhanced phosphorylation of Paralemmin 2, which may influence its membrane-associated functions. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Stimulates adenylyl cyclase through beta-adrenergic receptors, increasing cAMP and activating PKA, which potentially phosphorylates Paralemmin 2, affecting its cellular localization and function. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 activates G-protein coupled receptors that can increase cAMP levels, leading to PKA activation and potential phosphorylation of Paralemmin 2, modulating its activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Selective phosphodiesterase-4 inhibitor, increasing cAMP levels, thereby enhancing PKA activity and the subsequent phosphorylation and activity of Paralemmin 2 related to synaptic plasticity. | ||||||
8-CPT-cAMP | 93882-12-3 | sc-201569 sc-201569A | 20 mg 100 mg | $85.00 $310.00 | 19 | |
cAMP analog that activates PKA, leading to potential phosphorylation of Paralemmin 2, which could affect its interactions with the cytoskeleton and influence neuronal morphology. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Protein synthesis inhibitor that may activate stress-activated protein kinases which could phosphorylate Paralemmin 2, potentially influencing its function in neuronal development. | ||||||