Oxr1 Inhibitors
Chemical inhibitors of Oxr1 include a variety of compounds that exert their effects primarily through antioxidant mechanisms, thereby reducing the cellular oxidative stress that Oxr1 is known to respond to. Rosmarinic acid, for instance, is an effective scavenger of reactive oxygen species (ROS), which can lead to a reduced requirement for Oxr1 in mitigating oxidative damage within the cell. Apocynin, by inhibiting the assembly of NADPH oxidase, directly lowers the production of ROS, decreasing the oxidative burden where Oxr1 would be functionally relevant. Sodium pyruvate, as another example, scavenges hydrogen peroxide, reducing the peroxide-induced oxidative stress and consequently the cellular dependency on Oxr1.
Further supporting this reduction in Oxr1 reliance are chemicals like Mitoquinone mesylate, which specifically targets mitochondria to exert its antioxidant effects, diminish the oxidative conditions that necessitate Oxr1 function. Butylated hydroxyanisole (BHA) and Trolox, a vitamin E analog, prevent oxidative damage by scavenging free radicals and inhibiting lipid peroxidation, respectively, reducing the cellular need for Oxr1. Edaravone and Tempol act as free radical scavengers, with edaravone lowering oxidative stress and Tempol specifically dismutating superoxides, each leading to a reduced activation of Oxr1. Lastly, PDTC and Diphenyleneiodonium chloride (DPI) both inhibit NF-kB signaling and NADPH oxidase activity, respectively, with their antioxidant properties, thereby decreasing the functional demand for Oxr1 in protecting cells from oxidative stress.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rosmarinic Acid | 20283-92-5 | sc-202796 sc-202796A | 10 mg 50 mg | $57.00 $107.00 | 4 | |
Rosmarinic acid is an antioxidant that can inhibit reactive oxygen species (ROS). Oxr1 is known to be involved in the cellular response to oxidative stress. By reducing ROS, rosmarinic acid can inhibit the signaling that necessitates Oxr1 function for counteracting oxidative damage. | ||||||
Apocynin | 498-02-2 | sc-203321 sc-203321A sc-203321B sc-203321C | 1 g 10 g 100 g 500 g | $26.00 $67.00 $114.00 $353.00 | 74 | |
Apocynin inhibits the assembly and activation of NADPH oxidase, which is a primary source of ROS. By inhibiting NADPH oxidase, apocynin lowers ROS levels and thereby decreases the cellular need for Oxr1’s protective role against oxidative stress. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $284.00 | ||
Mitoquinone mesylate is targeted to mitochondria and exerts an antioxidant effect, thereby reducing mitochondrial oxidative stress. This can diminish the functional demand for Oxr1 in protecting cells from mitochondrial oxidative damage. | ||||||
Butylated hydroxyanisole | 25013-16-5 | sc-252527 sc-252527A | 5 g 100 g | $29.00 $96.00 | 1 | |
BHA is an antioxidant that can prevent oxidative stress by scavenging free radicals. By doing so, BHA can reduce the cellular reliance on Oxr1 for managing oxidative damage. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $37.00 $66.00 $230.00 $665.00 $1678.00 | 39 | |
Trolox is a vitamin E analog that functions as an antioxidant. It can inhibit lipid peroxidation, potentially reducing the need for Oxr1’s role in protecting cells from oxidative stress-related lipid damage. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
PDTC is an inhibitor of NF-kB activation and also acts as an antioxidant. By suppressing NF-kB signaling and oxidative stress, PDTC can decrease the cellular requirement for Oxr1 activity. | ||||||
TEMPOL | 2226-96-2 | sc-200825 | 1 g | $36.00 | 33 | |
Tempol is a stable free radical that can dismutate superoxides and act as an antioxidant. By mitigating superoxide-induced oxidative stress, Tempol can inhibit the functional activation of Oxr1. | ||||||
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $148.00 $133.00 $311.00 $397.00 $925.00 $1801.00 | 24 | |
DPI inhibits NADPH oxidase, which reduces the production of ROS. This can decrease the oxidative stress response that involves Oxr1, thus inhibiting the functional necessity for Oxr1 in the cell. | ||||||