OTTMUSG00000019145 Activators

Histidine-rich glycoprotein (HRG) is a multifunctional plasma protein that plays a critical role in various physiological processes, including the regulation of angiogenesis, coagulation, immune responses, and cell adhesion. HRG's structure allows it to interact with a wide range of ligands, including heparin, fibrinogen, and phospholipids, making it a key player in the modulation of these processes. The activation and function of HRG are influenced by these interactions, which can alter its conformation and consequently its activity.

The mechanisms of HRG activation and function are complex due to its ability to bind multiple ligands and its involvement in diverse biochemical pathways. Its activity can be modulated by changes in the concentrations of its binding partners or by alterations in the physiological or pathological state of the organism. For example, in the context of coagulation, HRG can bind to fibrinogen and heparin, balancing clot formation and breakdown. In angiogenesis, HRG's interaction with specific growth factors and inhibitors can either promote or inhibit new blood vessel formation. Understanding the exact mechanisms of HRG activation and its subsequent effects on various physiological processes remains a critical area of research.