Date published: 2025-10-25

1-800-457-3801

SCBT Portrait Logo
Seach Input

OR4K14 Inhibitors

Inhibitors of OR4K14 function through various mechanisms to attenuate the signaling and activity of this olfactory receptor, which is essential for the nuanced detection of odors. Compounds that affect the synthesis of signaling molecules within sensory neurons, such as those that inhibit cyclooxygenase enzymes, lead to reduced synthesis of prostaglandins, which can impact the sensitivity or expression of olfactory receptors like OR4K14. Additionally, certain molecules act on other sensory neuron receptors, such as transient receptor potential (TRP) channels, which can modulate the activity of olfactory receptor neurons, thereby influencing the function of OR4K14. For example, activation of TRPV1 or inhibition of TRPA1 may alter sensory neuron responses, which can have downstream effects on the activity of specific olfactory receptors. Moreover, various other chemicals interact with components of the neuronal signaling pathways, which can indirectly lead to the inhibition of OR4K14. Alkaloids that block voltage-gated potassium channels or compounds that inhibit sodium channels can affect the excitability of olfactory neurons, potentially reducing OR4K14 activity. Substances, such as adenosine receptor antagonists and nicotinic acetylcholine receptor agonists alter intracellular signaling cascades, and neurotransmitter release, which may indirectly impact the signaling mediated by olfactory receptors. Importantly, direct alteration to the olfactory epithelium by certain toxicants or surfactants can also result in the decreased activity of olfactory receptors like OR4K14, as the functional integrity of the olfactory epithelium is crucial for receptor activation and subsequent odorant signal transduction.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ibuprofen

15687-27-1sc-200534
sc-200534A
1 g
5 g
$52.00
$86.00
6
(0)

Inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis. Reduced prostaglandin levels may influence olfactory receptor sensitivity or expression, thus potentially decreasing OR4K14 activity.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$94.00
$173.00
$255.00
$423.00
26
(1)

Binds to the transient receptor potential vanilloid 1 (TRPV1), a sensory neuron receptor. TRPV1 activation can modulate olfactory receptor neurons, which may affect OR4K14 signaling.

Quinine

130-95-0sc-212616
sc-212616A
sc-212616B
sc-212616C
sc-212616D
1 g
5 g
10 g
25 g
50 g
$77.00
$102.00
$163.00
$347.00
$561.00
1
(0)

Blocks voltage-gated potassium channels, which are involved in the repolarization phase of action potentials in neurons. By altering neuronal activity, quinine could affect OR4K14 function in olfactory neurons.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
5 g
100 g
250 g
1 kg
5 kg
$32.00
$66.00
$95.00
$188.00
$760.00
13
(1)

Acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, increasing cAMP levels. Elevated cAMP may impact olfactory receptor neuron signaling and subsequently reduce the activity of OR4K14.

(−)-Menthol

2216-51-5sc-202705
sc-202705A
1 g
50 g
$20.00
$40.00
2
(1)

Agonist for transient receptor potential melastatin 8 (TRPM8) and antagonist for transient receptor potential ankyrin 1 (TRPA1). TRPM8 activation or TRPA1 inhibition may modulate sensory neuron responses, potentially influencing OR4K14 activity.

Copper(II) sulfate

7758-98-7sc-211133
sc-211133A
sc-211133B
100 g
500 g
1 kg
$45.00
$120.00
$185.00
3
(1)

Acts as an olfactory toxicant that can reduce olfactory receptor function. By damaging the olfactory epithelium, copper sulfate may indirectly inhibit OR4K14 activity.

Zinc

7440-66-6sc-213177
100 g
$47.00
(0)

Damages the olfactory epithelium. Zinc-induced epithelial damage could lead to decreased OR4K14 activity.

Lidocaine

137-58-6sc-204056
sc-204056A
50 mg
1 g
$50.00
$128.00
(0)

Blocks voltage-gated sodium channels, inhibiting action potential propagation in neurons. This inhibition could reduce signaling through neurons expressing OR4K14.

Eugenol

97-53-0sc-203043
sc-203043A
sc-203043B
1 g
100 g
500 g
$31.00
$61.00
$214.00
2
(1)

A compound found in clove oil that inhibits TRPV1 and TRPA1 receptors in sensory neurons. By modulating sensory receptor activity, eugenol could indirectly influence OR4K14 signaling.

Allicin

539-86-6sc-202449
sc-202449A
1 mg
5 mg
$460.00
$1428.00
7
(1)

A compound found in garlic that has been reported to modulate various ion channels and receptors in sensory neurons. Such modulation could lead to changes in olfactory receptor neuron activity, including OR4K14.