OR10W1 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin binds to the transient receptor potential vanilloid 1 (TRPV1) on sensory neurons, which can influence G-protein coupled receptor signaling, including OR10W1. When TRPV1 is activated, it can lead to the desensitization of local neurons, potentially decreasing the sensitivity and response of GPCRs like OR10W1 in the vicinity. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine is known to block potassium channels, which can alter the membrane potential and neuronal excitability. By modulating the neuronal environment, quinine can indirectly inhibit GPCR function, including OR10W1, by altering the polarization state of neurons, which is necessary for GPCR-mediated signal transduction. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine acts as a sodium channel blocker, preventing neuronal depolarization. This blockade can lead to a reduction in neuronal activity and neurotransmitter release, subsequently leading to a decrease in GPCR signaling, including the activity of OR10W1, by limiting the excitability of neurons that could engage OR10W1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenol that can modulate various signaling pathways, including sirtuins and AMPK. Through its action on these pathways, it can influence cellular processes that may lead to the downregulation of GPCRs, thereby indirectly inhibiting OR10W1 activity by promoting a cellular state less conducive to GPCR signaling. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is a beta-adrenergic antagonist that can inhibit adrenergic receptors, leading to a decrease in cyclic AMP levels. This reduction in cAMP can have downstream effects on other GPCRs by altering the intracellular signaling environment, potentially leading to the indirect inhibition of OR10W1 activity through a less active GPCR signaling milieu. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known to interact with various signaling molecules and has been shown to inhibit the activity of certain enzymes like COX-2. Through its enzyme inhibition, curcumin can affect prostaglandin synthesis, leading to changes in GPCR-signaling cascades, which could result in the indirect inhibition of OR10W1 function. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine acts as an antagonist of adenosine receptors, which can decrease intracellular cAMP through inhibitory G-proteins. The reduction in cAMP can indirectly inhibit the signaling of adjacent GPCRs, including OR10W1, by creating a cellular context of reduced GPCR-mediated signaling. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride functions as an inhibitor of epithelial sodium channels, which can affect the ionic balance across the cell membrane. By disrupting the sodium gradient, amiloride can indirectly inhibit GPCR activity, including OR10W1, as proper ionic gradients are crucial for GPCR signaling. | ||||||