Olr270 Activators
Chemical activators of Olr270 include a variety of compounds that influence different signaling pathways leading to the activation of this protein. BAY K8644 engages with Olr270 through the augmentation of intracellular calcium concentration by acting as an L-type calcium channel agonist. This increase in calcium ions can stimulate Olr270 if it's part of calcium-dependent signaling pathways. Similarly, calcium ionophores like ionomycin and A-23187 facilitate the transport of calcium ions into the cell, which, upon an influx, can activate Olr270 through related calcium-sensitive mechanisms. Thapsigargin also raises cytosolic calcium levels by inhibiting the SERCA pump, which could lead to the activation of Olr270 if it's regulated by or responsive to calcium-mediated signals.
On a different front, forskolin and dibutyryl-cAMP elevate the intracellular cAMP levels, which typically activate PKA. PKA, in turn, can phosphorylate Olr270, leading to its activation if Olr270 is within the scope of cAMP-dependent pathways. PMA activates PKC, which could phosphorylate Olr270, assuming it is a substrate for PKC or involved in a PKC-regulated pathway. On the other hand, anisomycin activates SAPKs, which might also phosphorylate and activate Olr270 if it is part of the SAPK pathway. Okadaic Acid and Calyculin A inhibit protein phosphatases 1 and 2A, potentially maintaining Olr270 in a phosphorylated state, thereby keeping it active. Pregnenolone sulfate, although its mechanism is less clear, can modulate various signaling pathways and may activate Olr270 by stimulating receptors or channels that are associated with the protein. Conversely, H-89 primarily inhibits PKA, but this inhibition can sometimes result in the compensatory activation of alternative pathways that might result in the activation of Olr270, depending on the signaling network within which Olr270 operates.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
BAY K8644 is a dihydropyridine compound that functions as an L-type calcium channel agonist. It induces calcium influx, which can activate Olr270 by increasing intracellular calcium concentration, leading to the activation of calcium-dependent signaling pathways that Olr270 is part of, thus directly causing an increase in Olr270 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration by transporting calcium ions across cell membranes. This influx of calcium ions can activate Olr270 by triggering calcium-sensitive pathways that Olr270 operates within, leading to its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activation of PKC can lead to phosphorylation of Olr270, assuming Olr270 is a substrate for PKC or is part of a pathway regulated by PKC phosphorylation, resulting in the functional activation of Olr270. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin acts as a protein synthesis inhibitor but also activates stress-activated protein kinases (SAPKs). The activation of SAPKs can lead to the phosphorylation and activation of Olr270, provided Olr270 is part of the SAPK pathway. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it prevents the dephosphorylation of proteins, potentially maintaining Olr270 in a phosphorylated and active state if Olr270 is subject to regulation by phosphorylation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways by elevating intracellular cAMP levels. This activation can result in the phosphorylation and activation of Olr270 through PKA or other cAMP-dependent kinases that Olr270 is regulated by. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A-23187 is a calcium ionophore similar to ionomycin, and it facilitates the influx of calcium ions into the cell. Increased intracellular calcium can activate signal transduction pathways that lead to the functional activation of Olr270 if it is responsive to calcium-mediated signaling. | ||||||
Pregnenolone sulfate sodium salt | 1852-38-6 | sc-301609 | 50 mg | $99.00 | 2 | |
Pregnenolone sulfate is a neurosteroid that can enhance neurotransmitter receptor activity and has been shown to modulate various signaling pathways. It can activate Olr270 by stimulating receptors or channels that Olr270 interacts with or is regulated by, leading to a downstream increase in Olr270 activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, like okadaic acid, is an inhibitor of protein phosphatases, particularly PP1 and PP2A. Its inhibition of these phosphatases can lead to the sustained activation of Olr270 if Olr270 is regulated by phosphorylation that would otherwise be reversed by these phosphatase activities. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump inhibitor, leading to an increase in cytosolic calcium levels. This elevation in calcium can activate Olr270 if it is part of or regulated by calcium-signaling pathways, leading to its functional activation. | ||||||