Olfr996, a member of the olfactory receptor family, is integral to the complex process of olfactory perception. Situated on the surface of olfactory sensory neurons, Olfr996 functions as a receptor dedicated to detecting specific odorant molecules present in the external environment. Its primary role lies in transducing chemical signals into neural impulses, which are then interpreted by the brain as distinct odors. The olfactory system, with Olfr996 at its core, plays a critical role in various aspects of an organism's survival, including food detection, predator avoidance, and social communication.
The activation of Olfr996 involves a precise and intricate series of events. It primarily relies on the direct binding of odorant molecules to the receptor, resulting in a conformational change that triggers downstream signaling pathways, including cAMP and MAPK. These pathways ultimately lead to the transmission of neural signals to the brain, where odor perception is experienced. Furthermore, Olfr996 can be influenced by specific chemicals that enhance its activation. These chemicals either bind directly to the receptor, making it more sensitive to odorant ligands, or indirectly impact Olfr996 by modulating GPCR signaling pathways or cGMP levels, ensuring efficient and functional activation of the receptor. This complex interplay of molecular interactions allows Olfr996 to contribute significantly to the fascinating world of olfaction, enabling organisms to perceive and interpret a diverse array of odors in their environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate is a ligand-specific activator of Olfr996. It binds to the receptor with high affinity, promoting a signaling cascade involving cAMP and MAPK pathways. This leads to receptor activation and subsequent olfactory signal transduction. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol acts as a positive allosteric modulator for Olfr996. It sensitizes the receptor to odorant ligands, effectively amplifying receptor activation and initiating downstream signaling events for olfactory perception. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
GTPγS enhances Olfr996 activation by stabilizing the active state of G-proteins linked to the receptor. This leads to prolonged intracellular signaling and sustained receptor activation, contributing to efficient odor detection. | ||||||
Isovaleric acid | 503-74-2 | sc-250205 | 100 ml | $29.00 | ||
Isovaleric Acid indirectly activates Olfr996 by modulating GPCR signaling pathways. It enhances the release of intracellular calcium, thereby increasing receptor sensitivity and facilitating the functional activation of Olfr996. | ||||||
Guanosine | 118-00-3 | sc-218575 sc-218575A sc-218575B sc-218575C sc-218575D | 5 g 25 g 250 g 1 kg 5 kg | $40.00 $50.00 $84.00 $250.00 $1103.00 | ||
Guanosine influences Olfr996 activation through the cGMP signaling pathway, an integral component of olfactory signal transduction. It elevates cGMP levels, leading to enhanced receptor activity and efficient odor perception. | ||||||