Olfr992 Activators
Olfr992, an olfactory receptor, is a member of the G-protein-coupled receptor (GPCR) family, integral to the sensory perception of odors. These receptors are responsible for detecting a wide array of chemical stimuli, translating these signals into a neuronal response that culminates in the perception of smell. The activation of Olfr992, as with other olfactory receptors, is highly specific and involves the binding of odorant molecules to the receptor. This interaction is pivotal in initiating a series of conformational changes within the receptor, which are essential for activating the intracellular signaling pathways. Upon binding of an odorant, Olfr992 undergoes a structural alteration, enabling its interaction with G-proteins. This interaction leads to the activation of adenylate cyclase, which catalyzes the conversion of ATP to cyclic AMP (cAMP). Elevated levels of cAMP subsequently activate protein kinase A (PKA), which phosphorylates various targets within the cell. These molecular events lead to the generation of a neuronal response, which is interpreted by the brain as a distinct odor. The specificity of ligand-receptor interactions in the olfactory system, as demonstrated by Olfr992 and its activators, underscores the complexity and precision of the olfactory system in detecting and differentiating between myriad odors.
The study of Olfr992 and its activation mechanisms provides valuable insights into the molecular underpinnings of olfaction and the broader principles of GPCR signaling. Understanding how specific chemicals interact with and activate this receptor enhances our knowledge of sensory perception and cellular communication. This information is crucial not only for comprehending the biology of smell but also has broader implications in fields such as neuroscience, pharmacology, and even the development of synthetic odorants. The primary focus here is on the basic understanding of Olfr992's role in olfactory perception. This approach is essential for advancing our understanding of sensory biology and the intricate mechanisms by which organisms interact with their environment at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr992 by binding to its orthosteric site, causing a conformational change that facilitates G-protein coupling. This activation leads to adenylate cyclase stimulation, increasing cyclic AMP levels, and activating PKA, functionally activating Olfr992. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate activates Olfr992 by binding to specific sites on the receptor, causing a conformational rearrangement. This rearrangement facilitates G-protein interaction and adenylate cyclase activation, increasing cyclic AMP production, leading to PKA activation and functional activation of Olfr992. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral activates Olfr992 through allosteric modulation, altering its conformation to enable effective G-protein coupling. This stimulates adenylate cyclase, elevating cyclic AMP levels, and activating PKA, thereby functionally activating Olfr992. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool activates Olfr992 by interacting with its ligand-binding domain, causing a structural change. This change leads to G-protein activation and adenylate cyclase stimulation, resulting in increased cyclic AMP levels and PKA activation, functionally activating Olfr992. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol activates Olfr992 by binding directly to the receptor, inducing a conformational change. This stimulates the G-protein signaling pathway, leading to adenylate cyclase activation, increased cyclic AMP levels, and subsequent PKA activation, thereby functionally activating Olfr992. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol activates Olfr992 through its interaction with specific binding sites, inducing structural alterations. These alterations facilitate G-protein coupling, leading to adenylate cyclase stimulation, increased cyclic AMP production, and PKA activation, functionally activating Olfr992. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol activates Olfr992 through allosteric modulation, altering the receptor's conformation. This alteration leads to G-protein coupling and activation, stimulating adenylate cyclase, increasing cyclic AMP levels, and activating PKA, thereby functionally activating Olfr992. | ||||||
Ethyl hexanoate | 123-66-0 | sc-235049 | 5 ml | $51.00 | ||
Ethyl hexanoate activates Olfr992 by binding to its orthosteric site, inducing a conformational change in the receptor. This leads to G-protein coupling, adenylate cyclase activation, increased cyclic AMP production, and PKA activation, functionally activating Olfr992. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptaldehyde activates Olfr992 through direct interaction with its binding domain, triggering a structural change. This change enables G-protein coupling and adenylate cyclase activation, increasing cyclic AMP production and PKA activation, thereby functionally activating Olfr992. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal activates Olfr992 by interacting with specific binding sites on the receptor, leading to a conformational shift. This shift facilitates G-protein coupling and activation, triggering adenylate cyclase, increasing cyclic AMP levels, and activating PKA, functionally activating Olfr992. | ||||||